Results 261 to 270 of about 132,574 (309)

The roles of heterogeneous nuclear ribonucleoproteins (hnRNP) in RNA metabolism

BioEssays, 1996
AbstractIn eukaryotic cells, messenger RNAs are formed by extensive posttranscriptional processing of primary transcripts, assembled with a large number of proteins and processing factors in ribonucleoprotein complexes. The protein moiety of these complexes mainly constitutes a class of about 20 major polypeptides called heterogeneous nuclear ...
F, Weighardt, G, Biamonti, S, Riva
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Low molecular weight RNAs as components of nuclear ribonucleoprotein particles containing heterogeneous nuclear RNA

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1979
70-130 S polyparticles as well as 38 S monoparticles were isolated from rat liver nuclei and analyzed in respect to their RNA components by microgel polyacrylamide electrophoresis in formamide. In addition to the high molecular weight polydisperse hnRNA of polyparticles several low molecular weight RNAs (snRNA) were detected.
Seifert, Hans, Scheurlen, Michael, Northemann, Wolfgang, Heinrich, Peter   +3 more
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Adenoviral heterogeneous nuclear RNA is associated with the host nuclear matrix during splicing

Journal of Molecular Biology, 1982
Abstract After infection of HeLa cells with adenovirus type 2, virus-specific heterogeneous nuclear RNA is quantitatively associated with a higher ordered structure, the nuclear matrix. Analysis of this matrix-associated RNA by S 1 nuclease mapping showed that precursors as well as processed messenger RNAs from the late region L4 were present.
E C, Mariman, C A, van Eekelen, R J, Reinders, A J, Berns, W J, van Venrooij   +4 more
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Isolation of a nuclear ribonucleoprotein network that contains heterogeneous RNA and is bound to the nuclear envelope

Biochemistry, 1975
Rapidly labeled polydispersed nuclear RNA is part of a ribonucleoprotein (RNP) network which in turn is tightly bound to the nuclear membrane. The membranous attachment, therefore, established a connection between chromatin and cytoplasm. The ultrastructure of the RNP network comprises fibrils and granules similar to those observed in intact nuclei ...
I, Faiferman, A O, Pogo
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Comparison of proteins bound to heterogeneous nuclear RNA and messenger RNA in HeLa cells

Journal of Molecular Biology, 1975
Abstract Ribonucleoprotein particles containing either heterogeneous nuclear RNA or polyribosomal messenger RNA were isolated from growing HeLa cells in order to compare their respective protein components. The major obstacle to analysing the proteins bound to HeLa cell mRNA proved to be the cosedimentation of a large fraction of the mRNP ...
A, Kumar, T, Pederson
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Developmental changes in the molecular weight of heterogeneous nuclear RNA

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1980
The size distribution of heterogeneous nuclear RNA (hnRNA) in the sea urchin embryo changes markedly during early development. Measurement of cleavage (4.5 h) to late gastrula (40 h) hnRNA by sedimentation in aqueous and denaturing solvent indicates that in the stages tested cleavage (4.5 h) hnRNA is smallest and rotating blastula (13 h) hnRNA is ...
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Heterogeneous nuclear RNA (HnRNA) size in developing frog embryos

Experimental Cell Research, 1979
Abstract Different stages of developing frog embryos were briefly labeled with [3H]uridine and the rapidly labeled RNA was denatured and sized by sucrose density gradient centrifugation. Studies of the accumulation of labeled nuclear and cytoplasmic RNA were employed to learn the extent of turnover of nuclear RNA.
G W, Shepherd, R, Flickinger
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Intermolecular duplexes in heterogeneous nuclear RNA from HeLa cells

Cell, 1977
Rapidly sedimenting hnRNA complexes contain regions of stable intermolecular duplex. Disruption of such complexes, as judged by a reduction in sedimentation rate, requires conditions sufficient to denature the duplex regions. Rapidly sedimenting molecules reappear only when the complementary sequences reanneal-that is, the formation of such complexes ...
N, Fedoroff, P K, Wellauer, R, Wall
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Proteins associated with heterogeneous nuclear RNA in eukaryotic cells

Journal of Molecular Biology, 1974
Abstract When HeLa cell nuclei axe mechanically disrupted in either hypotonic or isotonic buffers, heterogeneous nuclear RNA is recovered from the post-nucleolar fraction in the form of EDTA-resistant ribonucleoprotein particles, which sediment between 40 S and 250 S in sucrose gradients containing 0.01 m or 0.15 m -NaCl.
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Molecular classes of heterogeneous nuclear RNA in sea urchin embryos

Journal of Molecular Biology, 1975
Abstract Heterogeneous nuclear RNA of sea urchin blastulae has been fractionated into three molecular classes by two separate methods, using oligothymidylate (oligo(dT))-cellulose and polyuridylate (poly(U)) glass fiber filters. These molecular classes, which we have designated α, β and γ HnRNA ‡ , have distinctly different properties: (i) α HnRNA is
L M, Dubroff, M, Nemer
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