Results 91 to 100 of about 246,146 (311)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

The role of miRNA and lncRNA in heterotopic ossification pathogenesis

Stem Cell Research & Therapy, 2022
Heterotopic ossification (HO) is the formation of bone in non-osseous tissues, such as skeletal muscles. The HO could have a genetic or a non-genetic (acquired) background, that is, it could be caused by musculoskeletal trauma, such as burns, fractures ...
Łukasz Pulik, Bartosz Mierzejewski, Aleksandra Sibilska, Iwona Grabowska, Maria Anna Ciemerych, Paweł Łęgosz, Edyta Brzóska   +6 more
doaj   +1 more source

Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation

Circulation, 2019
Background: The majority of the human genome comprises noncoding sequences, which are in part transcribed as long noncoding RNAs (lncRNAs). lncRNAs exhibit multiple functions, including the epigenetic control of gene expression. In this study, the effect
S. Cremer, K. Michalik, A. Fischer, Larissa Pfisterer, Nicolas Jaé, Carla Winter, R. Boon, M. Muhly-Reinholz, D. John, S. Uchida, C. Weber, W. Poller, S. Günther, T. Braun, Dan Li, L. Maegdefessel, Ljubica Perisic Matic, U. Hedin, O. Soehnlein, A. Zeiher, S. Dimmeler   +20 more
semanticscholar   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation

Science Advances, 2019
HERV loci transcribed lncRNA TROJAN promotes TNBC progression through ZMYND8 degradation by the ubiquitin-proteasome pathway. Human endogenous retroviruses (HERVs) play pivotal roles in the development of breast cancer.
Xi Jin, Xiao-En Xu, Yizhou Jiang, Yirong Liu, Wei-li Sun, Y. Guo, Yifan Ren, W. Zuo, Xin Hu, Shenglin Huang, Hong-Jie Shen, F. Lan, Yun-Fei He, Guoxing Hu, G. Di, Xianghuo He, Da-Qiang Li, Suling Liu, Keda Yu, Z. Shao   +19 more
semanticscholar   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Downregulation of a novel long noncoding RNA TRPM2-AS promotes apoptosis in non–small cell lung cancer

Tumor Biology, 2017
Non–small cell lung cancer is one of the most common types of cancer, and the prognosis of non–small cell lung cancer is still poor. Recent evidence has proved that long noncoding RNA is involved in tumorigenesis.
Cheng Huang, Yingzhi Qin, Hongsheng Liu, Naixin Liang, Yeye Chen, Dongjie Ma, Zhijun Han, Xiaohui Xu, Xiaoyun Zhou, Jia He, Shanqing Li   +10 more
doaj   +1 more source

The role of noncoding RNAs in metabolic reprogramming of cancer cells

Cellular & Molecular Biology Letters, 2023
Metabolic reprogramming is a well-known feature of cancer that allows malignant cells to alter metabolic reactions and nutrient uptake, thereby promoting tumor growth and spread.
Amir Safi, Mohammadreza Saberiyan, Mohammad-Javad Sanaei, Samaneh Adelian, Fateme Davarani Asl, Mahsa Zeinaly, Mahdi Shamsi, Reza Ahmadi   +7 more
doaj   +1 more source

Regulation of CHD2 expression by the Chaserr long noncoding RNA gene is essential for viability

Nature Communications, 2019
Chromodomain helicase DNA binding protein 2 (Chd2) is a chromatin remodeller implicated in neurological disease. Here we show that Chaserr, a highly conserved long noncoding RNA transcribed from a region near the transcription start site of Chd2 and on ...
Aviv Rom, Liliya Melamed, Noa Gil, Micah Jonathan Goldrich, R. Kadir, Matan Golan, I. Biton, R. B. Perry, I. Ulitsky   +8 more
semanticscholar   +1 more source