Results 101 to 110 of about 246,146 (311)
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
Boundary Associated Long Noncoding RNA Mediates Long-Range Chromosomal Interactions. [PDF]
PLoS ONE, 2015 CCCTC binding factor (CTCF) is involved in organizing chromosomes into mega base-sized, topologically associated domains (TADs) along with other factors that define sub-TAD organization.
Ifeoma Jane Nwigwe +3 more
doaj +1 more source
Long Noncoding RNA and Epithelial Mesenchymal Transition in Cancer
International Journal of Molecular Sciences, 2019 Epithelial–mesenchymal transition (EMT) is a multistep process that allows epithelial cells to acquire mesenchymal properties. Fundamental in the early stages of embryonic development, this process is aberrantly activated in aggressive cancerous cells to
Mila Gugnoni, A. Ciarrocchi
semanticscholar +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Identification and function of long non-coding RNA
Frontiers in Cellular Neuroscience, 2013 Long non-coding (lnc) RNAs are defined as non-protein coding RNAs distinct from housekeeping RNAs such as tRNAs, rRNAs, and snRNAs, and independent from small RNAs with specific molecular processing machinery such as micro- or piwi-RNAs.
Carl eErnst, Cynthia C Morton
doaj +1 more source
Advanced Science, EarlyView.G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang +12 more
wiley +1 more source
The State of Long Non-Coding RNA Biology
Non-Coding RNA, 2018 Transcriptomic studies have demonstrated that the vast majority of the genomes of mammals and other complex organisms is expressed in highly dynamic and cell-specific patterns to produce large numbers of intergenic, antisense and intronic long non ...
John S. Mattick
doaj +1 more source
Long noncoding RNA expression profiling in cancer: Challenges and opportunities
Genes, Chromosomes and Cancer, 2019 In recent years, technological advances in transcriptome profiling revealed that the repertoire of human RNA molecules is more diverse and extended than originally thought.
L. Lorenzi +10 more
semanticscholar +1 more source
Long Noncoding RNAs and Hepatocellular Carcinoma
Gastroenterology, 2015 openAccessArticle: False ; cover date: 2015-02-01 ; pii: S0016-5085(14)01536-4 ; Harvest Date: 2016-01-06 13:07:54 ; issueName: ; Page Range: 291-291 ; href scidir: http://www.sciencedirect.com/science/article/pii/S0016508514015364 ; pubType ...
James F., Collins, Collins, James F.
openaire +3 more sources
Advanced Science, EarlyView.Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li +10 more
wiley +1 more source