Results 151 to 160 of about 246,146 (311)

Long Noncoding RNA and Cancer: A New Paradigm.

Cancer Research, 2017
A. Bhan, Milad Soleimani, S. Mandal
semanticscholar   +1 more source

Circular RNAs: Epigenetic Puppeteers Pulling the Strings of Cancer Pathogenesis

Medicine Bulletin, EarlyView.
ABSTRACT Circular RNAs (circRNAs), a unique class of endogenous noncoding RNAs characterized by their covalently closed loop structure, have emerged as pivotal players in cancer biology due to their exceptional stability, tissue‐specific expression, and diverse regulatory functions.
Yimao Wu, Zichang Chen, Junying Lee, Gokhan Zengin, Meng‐Yao Li   +4 more
wiley   +1 more source

E2E: An R Package for Easy‐to‐Build Ensemble Models

Med Research, EarlyView.
ABSTRACT E2E (Easy to Ensemble) is an R package aiming to provide researchers with a simple, user‐friendly, and comprehensive ensemble learning framework to address the challenges of existing tools when dealing with imbalanced data or constructing complex models.
Shanjie Luan, Ximing Wang
wiley   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

SNHG15: a promising cancer-related long noncoding RNA

Cancer Management and Research, 2019
Jinfei Tong,1,2 Xudong Ma,1,2 Hailan Yu,1,2 Jianhua Yang1,21Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;
Tong J, Ma X, Yu H, Yang J
doaj  

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Regulatory mechanisms of reproduction in locusts and grasshoppers

New Plant Protection, EarlyView.
Regulatory networks composed of numerous coding and noncoding genes play crucial roles in the reproduction of locusts and grasshoppers. This review integrates mechanistic advances in reproductive regulation, highlighting environmentally adaptive pathways and providing prospective targets for eco‐friendly pesticides.
Jing He, Jiliang Wang, Xinran Wang
wiley   +1 more source

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

Nature, 2011
Kevin C. Wang, Yul W Yang, Bo Liu, Amartya Sanyal, Ryan Corces-Zimmerman, Yong Chen, B. Lajoie, Angeline Protacio, Ryan A. Flynn, Rajnish A. Gupta, J. Wysocka, M. Lei, J. Dekker, J. Helms, Howard Y. Chang   +14 more
semanticscholar   +1 more source