Results 241 to 250 of about 8,401,372 (300)

Understanding extracellular vesicles in antiaging

open access: yesPeriodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad   +3 more
wiley   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

open access: yesBiological Reviews, Volume 101, Issue 6, Page 2471-2500, December 2026.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad   +5 more
wiley   +1 more source

Deubiquitinase USP5 suppresses ferroptosis in lung adenocarcinoma by deubiquitinating and stabilizing GPX3

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 4, December 2026.
1. USP5 overexpression in LUAD predicts poor prognosis, linking to tumor progression and therapy resistance. 2. USP5 deubiquitinates/stabilizes GPX3, maintaining antioxidant defense against ferroptosis. 3. Targeting inhibition of USP5 enhances LUAD ferroptosis sensitivity, offering therapeutic potential. Abstract Ferroptosis is a regulated form of cell
Xin Fan   +8 more
wiley   +1 more source

Pyroptosis in Preeclampsia: Placenta‐to‐Maternal Organ Communication, Molecular Mechanisms, and Therapeutic Targets

open access: yesComprehensive Physiology, Volume 16, Issue 6, December 2026.
Schematic diagram illustrating the potential mechanisms and core molecules contributing to the development of PE via mediating pyroptosis: focus on trophoblasts and endothelial cells. Pyroptosis of trophoblast cells in the placenta of preeclampsia not only inhibits its invasion, migration, and differentiation, causing local infiltration and ...
Xianyi Zhou   +5 more
wiley   +1 more source

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