Results 251 to 260 of about 111,170 (313)

CRISPR‐Based Gene Dependency Screens Reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer

open access: yesMolecular Carcinogenesis, Volume 65, Issue 7, Page 874-887, July 2026.
ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Shawn Noronha   +26 more
wiley   +1 more source

Revealing the cuproptosis-lncRNA nexus in gastric cancer: A multicohort observational study. [PDF]

open access: yesMedicine (Baltimore)
Zhou X   +11 more
europepmc   +1 more source

DDX21 Promotes Breast Cancer Growth and Metastasis via Stimulating RNAPII Elongation During Hypoxia

open access: yesMedComm, Volume 7, Issue 7, July 2026.
DDX21 triggers CDK9 release from the 7SK RNP complex. DDX21‐CDK9 binding to HIFs drives transcriptional reprogramming during hypoxia. DDX21 enhances breast cancer progression and metastasis. Elevated DDX21 expression correlates with poor prognosis in breast cancer patients.
Guangqiang Li   +11 more
wiley   +1 more source

Contradicting Kuhn's Popular Notion of Scientific Revolution: Conservative Revolutionaries in the History of Biology

open access: yesNatural Sciences, Volume 6, Issue 3, July 2026.
ABSTRACT Proposing the concept of a conservative revolutionary generally and using the examples of Gregor Mendel, Max Delbrück, and Eric Davidson, I fundamentally call into question Thomas Kuhn's ideas of scientific revolutions. I also highlight some problematic consequences of the increasing appreciation of Kuhn's work among scientists and show that ...
Ute Deichmann
wiley   +1 more source

To be or not to be a protein coding mutation, that's the question! [PDF]

open access: yesNAR Genom Bioinform
De Groote D   +3 more
europepmc   +1 more source

Epigenetic Regulation of Immune Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome

open access: yesThe Prostate, Volume 86, Issue 10, Page 1124-1133, July 2026.
ABSTRACT Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent and debilitating condition with unclear etiology. Increasing evidence implicates immune dysregulation, yet the molecular mechanisms underlying impaired immune regulation remain poorly defined. This study investigated the role of altered immune responses within
Praveen Thumbikat   +8 more
wiley   +1 more source

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