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Long Noncoding RNAs as Therapeutic Targets
2022Long noncoding RNAs (lncRNAs) have emerged as critical regulators of cellular functions including maintenance of cellular homeostasis as well as the onset and progression of disease. LncRNAs often exhibit cell-, tissue-, and disease-specific expression patterns, making them desirable therapeutic targets.
Jacob B, Pierce +3 more
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Long Noncoding RNAs and Cardiac Disease
Antioxidants & Redox Signaling, 2018Significance: To maintain homeostasis, gene expression has to be tightly regulated by complex and multiple mechanisms occurring at the epigenetic, transcriptional, and post-transcriptional levels. One crucial regulatory component is represented by long noncoding RNAs (lncRNAs), nonprotein-coding RNA species ...
Simona, Greco +3 more
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Long noncoding RNAs and cancer, an overview
Steroids, 2018Long noncoding RNAs (lncRNAs) are implicated in several biological processes, including but not limited to cardiovascular physiology, reproduction, differentiation, metabolism, DNA repair, and inflammation. Under normal physiological conditions, expression of lncRNAs is tissue-specific and tightly regulated.
Cristel V. Camacho +2 more
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Long noncoding RNA regulation of immunity
Nature ImmunologyGenes encoding long noncoding RNAs (lncRNAs) are intimately involved in mammalian immunity. Here we review recent knowledge of how lncRNAs regulate immune cell specification and function. Beyond canonical roles in nuclear architecture, chromatin modification and posttranscriptional regulation, lncRNA regulation of metabolic pathways, antigenic ...
Bingfei Yu, Howard Y. Chang
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Modulation of Noncoding RNAs (ncRNAs) and Their Potential Role as Therapeutics
Medical Epigenetics, 2021Luciano Pirola +2 more
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