Results 81 to 90 of about 246,146 (311)

ALDB: a domestic-animal long noncoding RNA database. [PDF]

PLoS ONE, 2015
Long noncoding RNAs (lncRNAs) have attracted significant attention in recent years due to their important roles in many biological processes. Domestic animals constitute a unique resource for understanding the genetic basis of phenotypic variation and ...
Aimin Li, Junying Zhang, Zhongyin Zhou, Lei Wang, Yujuan Liu, Yajun Liu   +5 more
doaj   +1 more source

Human Long Noncoding RNA Interactome: Detection, Characterization and Function

International Journal of Molecular Sciences, 2020
The application of a new generation of sequencing techniques has revealed that most of the genome has already been transcribed. However, only a small part of the genome codes proteins.
Marek Kazimierczyk, Marta Kasprowicz, M. Kasprzyk, J. Wrzesinski   +3 more
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A noncoding RNA containing a SINE-B1 motif associates with meiotic metaphase chromatin and has an indispensable function during spermatogenesis. [PDF]

PLoS ONE, 2017
A search for early response genes that are activated following germ cell induction from mouse embryonic stem cells in vitro led us to the isolation of a long noncoding RNA that contains a SINE (short interspersed element)-B1F motif that was named R53. In
Ryusuke Nakajima, Takuya Sato, Takehiko Ogawa, Hideyuki Okano, Toshiaki Noce   +4 more
doaj   +1 more source

Long noncoding RNAs in viral infections [PDF]

Virus Research, 2016
Viral infections induce strong modifications in the cell transcriptome. Among the RNAs whose expression is altered by infection are long noncoding RNAs (lncRNAs). LncRNAs are transcripts with potential to function as RNA molecules. Infected cells may express viral lncRNAs, cellular lncRNAs and chimeric lncRNAs formed by viral and cellular sequences ...
Fortes, Puri, Morris, Kevin V
openaire   +3 more sources

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN

Journal of Clinical Investigation, 2019
Noncoding RNAs are emerging as important players in gene regulation and disease pathogeneses. Here, we show that a previously uncharacterized long noncoding RNA, nexilin F-actin binding protein antisense RNA 1 (NEXN-AS1), modulates the expression of the ...
Yan-Wei Hu, Fengxia Guo, Yuan-Jun Xu, Pan Li, Zhi-Feng Lu, D. McVey, Lei Zheng, Qian Wang, John H. Ye, Chunmin Kang, Shao-Guo Wu, Jing-jing Zhao, Xin Ma, Zhen-yu Yang, Fuchun Fang, Y. Qiu, Bang-Ming Xu, Lei Xiao, Qian Wu, Li-mei Wu, Li-Na Ding, T. Webb, N. Samani, S. Ye   +23 more
semanticscholar   +1 more source

Visualizing Long Noncoding RNAs on Chromatin [PDF]

, 2016
Fluorescence in situ hybridization (FISH) enables the detection of specific nucleic acid sequences within single cells. For example, RNA FISH provides information on both the expression level and localization of RNA transcripts and, when combined with detection of associated proteins and chromatin modifications, can lend essential insights into long ...
Michael, Hinten, Emily, Maclary, Srimonta, Gayen, Clair, Harris, Sundeep, Kalantry   +4 more
openaire   +2 more sources

Cytoplasmic functions of long noncoding RNAs [PDF]

WIREs RNA, 2018
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides found throughout the cell that lack protein‐coding function. Their functions are closely linked to their interaction with RNA‐binding proteins (RBPs) and nucleic acids. Nuclear lncRNAs have been studied extensively, revealing complexes with structural and regulatory roles that ...
Ji Heon, Noh, Kyoung Mi, Kim, Waverly G, McClusky, Kotb, Abdelmohsen, Myriam, Gorospe   +4 more
openaire   +2 more sources

Long noncoding RNAs in cancer metastasis

Nature Reviews Cancer, 2021
Metastasis is a major contributor to cancer-associated deaths. It is characterized by a multistep process that occurs through the acquisition of molecular and phenotypic changes enabling cancer cells from a primary tumour to disseminate and colonize at distant organ sites. Over the past decade, the discovery and characterization of long noncoding RNAs (
S. John Liu, Ha X. Dang, Daniel A. Lim, Felix Y. Feng, Christopher A. Maher   +4 more
openaire   +3 more sources