Results 91 to 100 of about 547,696 (232)

Nucleotide bias of DCL and AGO in plant anti-virus gene silencing [PDF]

, 2010
Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing ...
Dalmay, Tamas, Ho, Thien, Huang, Linfeng, Li, Zhigang, Ohshima, Kazusato, Pallett, Denise W., Walsh, John A., Wang, Hui, Wang, Liang   +8 more
core   +1 more source

EGCG‐LYS Fibrils‐Mediated CircMAP2K2 Silencing Decreases the Proliferation and Metastasis Ability of Gastric Cancer Cells in Vitro and in Vivo

Advanced Science, 2023
Aberrant expression of circular RNAs (circRNAs) has been reported to play an important biological regulatory role in gastric cancer (GC). For the purpose of silencing cancer‐related genes, a new approach for cancer treatment using nanocarriers to deliver
Jiaqi Dong, Zhousan Zheng, Mi Zhou, Yunfei Wang, Jiajie Chen, Junjie Cen, Tiefeng Cao, Taowei Yang, Yi Xu, Guannan Shu, Xuanxuan Lu, Yanping Liang   +11 more
doaj   +1 more source

Silencing of bach1 gene by small interfering RNA–mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells

Tumor Biology, 2017
Background: Recently experimental validation of the networks revealed bach1, a basic leucine zipper transcription factor, as the common regulator of several functional invasive genes.
Reza Mohammadzadeh, Mojgan Saeid Harouyan, Seyed Mansour Ale Taha   +2 more
doaj   +1 more source

Characterization of a broad-based mosquito yeast interfering RNA larvicide with a conserved target site in mosquito semaphorin-1a genes [PDF]

, 2019
BACKGROUND: RNA interference (RNAi), which has facilitated functional characterization of mosquito neural development genes such as the axon guidance regulator semaphorin-1a (sema1a), could one day be applied as a new means of vector control ...
Duman-Scheel, Molly, Hapairai, Limb K., Li, Ping, Mysore, Keshava, Realey, Jacob S., Scheel, Nicholas D., Severson, David W., Sun, Longhua, Wang, Chien-Wei, Wei, Na   +9 more
core   +1 more source

siRNA-mediated silencing of bFGF gene inhibits the proliferation, migration, and invasion of human pituitary adenoma cells

Tumor Biology, 2017
Human pituitary adenoma is one of the most common intracranial tumors with an incidence as high as 16.7%. Recent evidence has hinted a relationship between growth factors of pituitary or hypothalamic origin and proliferation of human pituitary adenoma ...
Kai Zhou, Yan-Dong Fan, Serick Duysenbi, Peng-Fei Wu, Zhao-Hai Feng, Zheng Qian, Ting-Rong Zhang   +6 more
doaj   +1 more source

Small interfering RNA effect on lipoprotein(a): a systematic review

The Egyptian Heart Journal
Background This systematic review investigates the effect of small interfering RNA (siRNA) therapies on lipoprotein(a) [Lp(a)] levels. The purpose is to evaluate the outcomes of recent randomized controlled trials (RCTs) involving siRNA treatments aimed ...
Omar Almaadawy, Mohamed Mar’ey Hesn, Yomna Ayman Elsalamony, Omar Ayman Abobakr, Abdelrahman Hossam Elshimy, Khaled Alsayed Abulkhair, Mahmoud Mohamed Negm, Ahmed Yasser Shaban, Yakubu Bene-Alhasan, Frank Annie, Adam Belcher, Ahmed Ramy Elashery   +11 more
doaj   +1 more source

Delivery of small-interfering RNA (siRNA) to the brain [PDF]

Expert Opinion on Therapeutic Patents, 2009
Two fundamental difficulties in the delivery of drugs to treat central nervous system (CNS) diseases are the systemic delivery of therapeutics across the bloodbrain-barrier (BBB), and the targeting of drugs to specific tissues or cells within the brain.
openaire   +3 more sources

HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide. [PDF]

, 2006
microRNAs (miRNAs) and small interfering RNAs (siRNAs) in plants bear a methyl group on the ribose of the 3' terminal nucleotide. We showed previously that the methylation of miRNAs and siRNAs requires the protein HEN1 in vivo and that purified HEN1 ...
Chen, Xuemei, Ebright, Yon W, Yang, Zhiyong, Yu, Bin   +3 more
core   +2 more sources

The role of virus-derived small interfering RNAs in RNA silencing in plants

Science China Life Sciences, 2012
Antiviral defense is one of the important roles of RNA silencing in plants. Virus-derived small interfering RNAs (vsiRNAs) are found in the infected host cells, indicating that the host RNA silencing machinery can target viral RNAs for destruction.
Hui Zhu, Huishan Guo
semanticscholar   +1 more source

Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants

Pharmaceuticals
RNA interference (RNAi) was originally regarded as a mechanism of eukaryotic post-transcriptional gene regulation mediated by small interfering RNA (siRNA)-induced sequence-specific RNA degradation.
Hara Kang, Yun Ji Ga, Jung Won Kim, Chaeyeon Kim, Se-Hwan Son, Chaeeun Gwak, Jung-Yong Yeh   +6 more
doaj   +1 more source