Results 101 to 110 of about 348,149 (303)

Structural insights into RNA processing by the human RISC-loading complex. [PDF]

, 2009
Targeted gene silencing by RNA interference (RNAi) requires loading of a short guide RNA (small interfering RNA (siRNA) or microRNA (miRNA)) onto an Argonaute protein to form the functional center of an RNA-induced silencing complex (RISC).
AD Haase, B Kastner, Bunpote Siridechadilok, C Matranga, Cameron Noland, David W Taylor, DS Schwarz, E Bernstein, E Ma, EF Pettersen, Enbo Ma, Eva Nogales, F Herzog, FV Rivas, H Gao, Hong-Wei Wang, IJ MacRae, IJ MacRae, IJ MacRae, JB Preall, Jennifer A Doudna, JJ Song, Karin Felderer, KH Kok, M Högbom, M Radermacher, M van Heel, PA Penczek, SH Scheres, SJ Ludtke, T Sasaki, TA Rand, TM Rana, TP Chendrimada, W Wriggers, Y Lee, Y Tomari, Y Tomari, Y Wang, Y Wang, YR Yuan, YR Yuan   +41 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Generation of Virus- and dsRNA-Derived siRNAs with Species-Dependent Length in Insects

Viruses, 2019
Double-stranded RNA (dsRNA) molecules of viral origin trigger a post-transcriptional gene-silencing mechanism called RNA interference (RNAi). Specifically, virally derived dsRNA is recognized and cleaved by the enzyme Dicer2 into short interfering RNAs ...
Dulce Santos, Lina Mingels, Elise Vogel, Luoluo Wang, Olivier Christiaens, Kaat Cappelle, Niels Wynant, Yannick Gansemans, Filip Van Nieuwerburgh, Guy Smagghe, Luc Swevers, Jozef Vanden Broeck   +11 more
doaj   +1 more source

RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes [PDF]

, 2008
Macrophages are crucial for innate immunity, apoptosis, and tissue remodeling, processes that rely on the capacity of macrophages to internalize and process cargo through phagocytosis.
Rajesh Jayachandran, John Gatfield, Jan Massner, Imke Albrecht, Bettina Zanolari, Jean Pieters, Sandra Schmid, Aderem A., Allen L. A., Araki N., Brummelkamp T. R., David V., de Hostos E. L., de Hostos E. L., de Hostos E. L., Ferrari G., Ferrari G., Foger N., Gatfield J., Gerisch G., Goode B. L., Grogan A., Guerin I., Heil-Chapdelaine R. A., Humphries C. L., Itoh S., Jayachandran R., Johannes L., Maniak M., Nal B., Nguyen L., Okumura M., Pantaloni D., Parente J. A., Pieters J., Rybakin V., Scherr N., Schuller S., Smith T. F., Steinman R. M., Suzuki K., Tailleux L., Tulp A., Vieira O. V., Walburger A., Zheng P. Y.   +45 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Decrease in gyrase A protein expression in _E. coli_ cells inhibited by antisense ribozymes [PDF]

, 2008
RNase P complexed with external guide sequence (EGS) represents a novel nucleic-acid-based gene interference approach to modulate gene expression. Nucleic acid-based gene interference technologies represent promising strategies for specific inhibition of
Malathi Raghunathan, Shilpakala Sainath Rao   +1 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

RNAi Therapeutics in Autoimmune Disease

Pharmaceuticals, 2013
Since the discovery of RNA interference (RNAi), excitement has grown over its potential therapeutic uses. Targeting RNAi pathways provides a powerful tool to change biological processes post-transcriptionally in various health conditions such as cancer ...
Seunghee Cha, Kaleb M. Pauley
doaj   +1 more source

Iron oxide nanoparticles and derivatives for biomedical imaging and application in cancer diagnosis and siRNA therapy [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011), Medarova, Z, Yigit, MV   +2 more
core  

Small interfering RNA-producing loci in the ancient parasitic eukaryote Trypanosoma brucei [PDF]

, 2012
BACKGROUND: At the core of the RNA interference (RNAi) pathway in Trypanosoma brucei is a single Argonaute protein, TbAGO1, with an established role in controlling retroposon and repeat transcripts.
Christian Tschudi, Elisabetta Ullu, Huafang Shi, Joseph B Franklin   +3 more
core   +1 more source