Results 211 to 220 of about 214,664 (246)

Inhibition of PTTG1 suppresses proliferation and promotes differentiation of neuroblastoma cells by inducing autophagy. [PDF]

Pediatr Surg Int
Yuan L, Wang X, Dai K, Wong KKY.
europepmc   +1 more source

The current and future landscape of RNA-based therapies and diagnostics. [PDF]

Commun Med (Lond)
Freije CA, Arechavala-Gomeza V.
europepmc   +1 more source

C16-siRNAs in Focus: Development of ALN-APP, a Promising RNAi-Based Therapeutic for Alzheimer's Disease. [PDF]

Pharmaceuticals (Basel)
Titze-de-Almeida R, Oliveira Gomes GM, Santos TCD, Titze-de-Almeida SS.   +3 more
europepmc   +1 more source

Correction: Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis. [PDF]

Cytotechnology
Fang Y, E C, Wu S, Meng Z, Qin G, Wang R.   +5 more
europepmc   +1 more source

Non-coding RNAs in laryngeal squamous cell carcinoma: diagnostic biomarkers and emerging exosome-based therapeutic strategies. [PDF]

Cancer Cell Int
Elgormus MN, Biltekin B, Ibas M.
europepmc   +1 more source

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Small interfering RNA (siRNA)-based therapeutics

Drug and Therapeutics Bulletin, 2023
In early studies in simple organisms and mammalian cell lines, small interfering RNA (siRNA) molecules were found to allow experimental cleavage of intracellular messenger RNA (mRNA; the transcription product of a cell gene), reducing the levels of the proteins that would otherwise be formed by the action of the mRNA, thereby ‘silencing’ a specific ...
openaire   +2 more sources

RNA Interference and Small Interfering RNAs

ChemBioChem, 2001
The term aRNA interferenceo (RNAi) was coined after the groundbreaking discovery that injection of double-stranded RNA (dsRNA) into the nematode Caenorhabditis elegans leads to specific silencing of genes highly homologous in sequence to the delivered dsRNA.
openaire   +3 more sources

Chemical Modification of Small Interfering RNA

2011
Chemically synthesized siRNAs are widely used for gene silencing. For in vitro applications, stability, delivery, and immunological issues are rarely problematic, but for in vivo applications the situation is different. Limited stability, undesirable pharmacokinetic behaviour, and unanticipated side effects from the immune system call for more careful ...
Bramsen, Jesper Bertram, Kjems, Jørgen
openaire   +2 more sources

Small Interfering RNA for Effective Cancer Therapies

Mini-Reviews in Medicinal Chemistry, 2011
Small interfering RNA (siRNA) has become a specific and powerful tool to turn off the expression of target genes, and has turned into a promising tool in molecular medicine. It can be targeted against cancer by several strategies. These include the suppression of overexpressed oncogenes, retarding cell division by interfering with cyclins and related ...
X, Wang, Y, Chen, J, Ren, X, Qu
openaire   +2 more sources