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Small Interfering RNAs and RNA Therapeutics in Cardiovascular Diseases
2020Ribonucleic acid (RNA) is being exploited and understood in its many aspects of function and structure for development of valuable tools in the therapeutics of various diseases such as cardiovascular etc. The expanded knowledge regarding function of RNA in the genomics and inside the cell has dramatically changed the therapeutic strategies in the past ...
Parveen, Bansal, Malika, Arora
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Small interfering RNA (siRNA)-based therapeutics
Drug and Therapeutics Bulletin, 2023In early studies in simple organisms and mammalian cell lines, small interfering RNA (siRNA) molecules were found to allow experimental cleavage of intracellular messenger RNA (mRNA; the transcription product of a cell gene), reducing the levels of the proteins that would otherwise be formed by the action of the mRNA, thereby ‘silencing’ a specific ...
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Oncogene Suppression by Small Interfering RNAs
Current Pharmaceutical Biotechnology, 2004Almost all human cancers have accumulated multiple genetic lesions including oncogenes. It is often unknown whether an oncogene is continuously required for tumorigenesis. Furthermore, it is very difficult to target an essential oncogene with drugs without affecting the corresponding nonmutated protooncogene or related factors.
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Gene silencing in mammals by small interfering RNAs
Nature Reviews Genetics, 2002Among the 3 billion base pairs of the human genome, there are approximately 30,000-40,000 protein-coding genes, but the function of at least half of them remains unknown. A new tool - short interfering RNAs (siRNAs) - has now been developed for systematically deciphering the functions and interactions of these thousands of genes.
Michael T, McManus, Phillip A, Sharp
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RNA interference and chemically modified small interfering RNAs
Current Opinion in Chemical Biology, 2004RNA interference (RNAi) is a powerful biological process for specific silencing of gene expression in diversified eukaryotic cells and has tremendous potential for functional genomics, drug discovery through in vivo target validation, and development of novel gene-specific medicine.
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Inhibition of HCV Replication by Small Interfering RNA
2009Small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) have been reported to suppress gene expression significantly. HCV seems a suitable candidate for targets of siRNAs, as HCV is a positive single-strand RNA virus and replicates in the cytoplasm.
Ratna B, Ray, Tatsuo, Kanda
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On the delivery of small interfering RNAs into mammalian cells
Expert Opinion on Drug Delivery, 2005RNA interference is becoming the technique of choice for analysing gene function and drug target validation. In this process, sequence-specific gene inhibition is initiated by small RNA duplexes, known as small interfering RNAs (siRNAs). The possibility that exogenously delivered siRNAs or endogenously expressed hairpin siRNAs can cause the destruction
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Photocaged Small Interfering RNA
Russian Journal of Bioorganic Chemistry, 2022E. A. Akhmetova +4 more
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Polycatechol Mediated Small Interfering RNA Delivery for the Treatment of Ulcerative Colitis
Advanced Functional Materials, 2021Yiyun Cheng, Yiwen Li
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