Results 51 to 60 of about 331,612 (290)

cd26 Knockdown Negatively Affects Porcine Parthenogenetic Preimplantation Embryo Development

Animals, 2022
cd26 is ubiquitously distributed in the body, particularly in the endothelial and epithelial cells, with the highest expression in the kidney, liver, and small intestine. In humans, cd26 serves as a marker for the embryo implantation phase.
In-Sul Hwang, Joohyun Shim, Keon Bong Oh, Haesun Lee, Mi-Ryung Park   +4 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Small interfering RNA: potential in real-world clinical practice

Реальная клиническая практика: данные и доказательства
This review describes the basics of protein biosynthesis and RNA interference processes, discusses the useful and unique properties of siRNA therapy, its advantages and disadvantages in comparison with other gene silencing methods, provides a brief ...
A. S. Motrinchuk, A. R. Kasimova
doaj   +1 more source

Application of small RNA technology for improved control of parasitic helminths [PDF]

, 2015
Over the last decade microRNAs (miRNAs) and small interfering RNAs (siRNAs) have emerged as important regulators of post-transcriptional gene expression.
Britton, Collette, Devaney, Eileen, Gillan, Victoria, Gu, Henry, Marks, Neil D., McNeilly, Tom N., Winter, Alan D.   +6 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

The promise and progress of RNA-interference-based antiviral therapy for respiratory syncytial virus.

Журнал инфектологии, 2014
Respiratory syncytial virus (RSV) is a major cause of morbidity in infants, young children, and the elderly worldwide. Presently, there are no explicit recommendations for RSV treatment apart from supportive care.
V. V. Vysochinskayа, E. V. Esaulenko, A. A. Bogdanov, D. N. Ghorab, N. A. Кnyazev, M. V. Dubina   +5 more
doaj   +1 more source

Design of LNA-modified siRNAs against the highly structured 5′ UTR of coxsackievirus B3 [PDF]

, 2008
This study describes a strategy to develop LNA-modified small interfering RNA (siRNAs) against the highly structured 5′ UTR of coxsackievirus B3 (CVB-3), which is an attractive target site due to its high degree of conservation.
Dutkiewicz, Mariola, Grunert, Hans-Peter, Kurreck, Jens, Lena, Suzy W., Wengel, Jesper, Zeichhardt, Heinz   +5 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Binding of small interfering RNA molecules is crucial for RNA interference suppressor activity of rice hoja blanca virus NS3 in plants [PDF]

, 2009
The NS3 protein of rice hoja blanca tenuivirus represents a viral suppressor of RNAi that sequesters small interfering (si)RNAs in vitro. To determine whether this siRNA binding property is the critical determinant for the suppressor activity of NS3, an ...
Goldbach, R.W., Hemmes, J.C., Kaaij, L., Lohuis, H., Prins, M.W., Schnettler, E.   +5 more
core   +2 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source