Results 251 to 260 of about 7,392,133 (313)

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

Author Correction: RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R. [PDF]

Nat Commun
Badrani JH, Strohm AN, Lacasa L, Civello B, Cavagnero K, Huang YA, Amadeo M, Naji LH, Lund SJ, Leng A, Kim H, Baum RE, Khorram N, Mondal M, Seumois G, Pilotte J, Vanderklish PW, McGee HM, Doherty TA.   +18 more
europepmc   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

Poly(A)-binding proteins act as a thermosensory switch to control flowering via cytoplasmic retention of RNA-binding protein 45C. [PDF]

Sci Adv
Yan A, Gong X, Zhang S, Chen J, Yu H.
europepmc   +1 more source

pH‐Responsive Synthetic Cells for Programmable In Situ Protein Synthesis and Release

Advanced Materials, EarlyView.
A synthetic cell is engineered to convert environmental acidification into nucleic acid signaling that activates protein synthesis. By coupling proton‐channel sensing, pH‐responsive DNA transduction, and toehold‐regulated translation, the platform enables acid‐triggered protein production within hydrogel‐embedded synthetic cells.
Sung‐Won Hwang, Yudan Li, Alexander A. Green, Allen P. Liu   +3 more
wiley   +1 more source

RNA-binding protein family diversification correlates with neural complexity across metazoan evolution. [PDF]

iScience
Yasuda K.
europepmc   +1 more source

The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis. [PDF]

Am J Physiol Gastrointest Liver Physiol
Swift KA, Shumway AJ, Aloia M, Hedges M, Pung R, Liu M, Rodriguez Santiago C, Shanahan MT, Drake A, Hakar MH, Selesner L, Kuhn M, Yung C, Sethupathy P, Andres SF.   +14 more
europepmc   +1 more source

Correction: Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation.

Elife
Hoekstra MMB, Emmenegger Y, Hubbard J, Franken P.   +3 more
europepmc   +1 more source

Functional analysis of natural variation in the RNA-binding protein CsrA across the bacterial domain predicts regulatory activity. [PDF]

Nucleic Acids Res
Winkelman JT, Yarberry E, Fanouraki G, Winkelman JD, Mukherjee S.   +4 more
europepmc   +1 more source