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Copy Number Amplification and c-Myc Transcriptional Activation-Mediated RNA-Binding Protein MEX3A Promotes EGFR-TKI Resistance in Non-Small-Cell Lung Cancer. [PDF]

Thorac Cancer
Xiling S, Lin D, Jiali D, Chen Z, Ruohan H, Chang Z, Renhua G, Jun L.   +7 more
europepmc   +1 more source

RNA-binding proteins in bacteria [PDF]

Nature Reviews Microbiology, 2018
RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal proteins, studies of bacterial RBPs have paved the way for molecular studies of RNA-protein interactions.
Erik Holmqvist, Jörg Vogel, Holmqvist Erik   +2 more
exaly   +4 more sources

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RNA binding proteins and selenocysteine

BioFactors, 2001
AbstractSelenocysteine is incorporated into protein by a complex co‐translational mechanism that involves both cis and trans acting factors. Among the trans‐acting factors are RNA binding proteins that interact with the selenoprotein 3′ UTRs at a sequence known as the selenocysteine insertion sequence (SECIS). These factors are generally referred to as
P R, Copeland, D M, Driscoll
openaire   +2 more sources

RNA-binding protein kinetics

Nature Methods, 2021
KIN-CLIP allows determination of binding and dissociation kinetics of RNA-binding proteins in cells.
openaire   +2 more sources

Plant RNA-binding proteins

Molecular Biology Reports, 1990
We have recently shown that although pre-mRNA splicing in plants shares some features in common with splicing in vertebrates, there are some crucial differences. In plants there is a requirement for a general enrichment for A+U within the intron and there is no requirement for a 3 ' polypyrimidine tract (Goodall and Filipowicz, 1989).
Goodall G, Levy J, Mieszczak M, Filipowicz W   +3 more
openaire   +3 more sources

Nuclear RNA-binding Proteins

1991
Publisher Summary The control of gene expression involves several steps at which specific sequences in pre-mRNA transcripts, as well as those in small RNA molecules, are recognized by proteins. RNA-binding proteins can be expected to mediate interactions in a variety of cellular processes, including those occurring in the transcription complex, the ...
J D, Keene, C C, Query
openaire   +2 more sources

RNA-binding protein dysfunction in neurodegeneration

Essays in Biochemistry, 2021
Abstract Protein homeostasis (proteostasis) is a prerequisite for cellular viability and plasticity. In particular, post-mitotic cells such as neurons rely on a tightly regulated safeguard system that allows for regulated protein expression.
Bastian Popper, Tom Scheidt, Rico Schieweck   +2 more
openaire   +2 more sources

Drosophila RNA Binding Proteins

2006
RNA binding proteins are fundamental mediators of gene expression. The use of the model organism Drosophila has helped to elucidate both tissue-specific and ubiquitous functions of RNA binding proteins. These proteins mediate all aspects of the mRNA lifespan including splicing, nucleocytoplasmic transport, localization, stability, translation, and ...
Chiara, Gamberi, Oona, Johnstone, Paul, Lasko   +2 more
openaire   +2 more sources

Purification of RNA-Binding Proteins

2014
The majority of regulatory RNA sequences exert their function through interaction with proteins. Therefore, the identification of RNA-binding proteins is the key step in understanding the role of many RNA motifs. Here, we describe a straightforward method to identify RNA-binding proteins.
Birgit, Ritter, Marc R, Reboll
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Circular RNAs Binding to RNA-Binding Proteins

High-throughput RNA sequencing yields novel noncoding RNAs called circular RNAs (circRNAs). They are extensively distributed across the transcriptomes of humans and other metazoans. Research has demonstrated their critical functions in multiple cellular developmental processes and diseases, including cancer, cognitive disorders, and neurodegenerative ...
Mandakini, Singh, Kirthik, Roshan, Srinivasan, Muthuswamy, Ajay, Kumar, Santosh, Kumar   +4 more
openaire   +2 more sources