Results 31 to 40 of about 1,877,035 (363)

De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function. [PDF]

, 2014
The splicing regulator Polypyrimidine Tract Binding Protein (PTBP1) has four RNA binding domains that each binds a short pyrimidine element, allowing recognition of diverse pyrimidine-rich sequences.
Black, Douglas L, Fu, Xiang-Dong, Han, Areum, Linares, Anthony J, Stoilov, Peter, Zhou, Yu   +5 more
core   +4 more sources

Pat1 RNA‐binding proteins: Multitasking shuttling proteins [PDF]

WIREs RNA, 2019
AbstractPost‐transcriptional regulation of gene expression is largely achieved at the level of splicing in the nucleus, and translation and mRNA decay in the cytosol. While the regulation may be global, through the direct inhibition of central factors, such as the spliceosome, translation initiation factors and mRNA decay enzymes, in many instances ...
Vindry, Caroline, Weil, Dominique, Standart, Nancy   +2 more
openaire   +3 more sources

Real-time assembly of ribonucleoprotein complexes on nascent RNA transcripts. [PDF]

, 2018
Cellular protein-RNA complexes assemble on nascent transcripts, but methods to observe transcription and protein binding in real time and at physiological concentrations are not available.
Duss, Olivier, Grot, Annette, O'Leary, Seán E, Puglisi, Joseph D, Stepanyuk, Galina A, Williamson, James R   +5 more
core   +2 more sources

Transcriptionally inactive oocyte-type 5S RNA genes of Xenopus laevis are complexed with TFIIIA in vitro [PDF]

, 1987
An extract from whole oocytes of Xenopus laevis was shown to transcribe somatic-type 5S RNA genes approximately 100-fold more efficiently than oocyte-type 5S RNA genes.
Eversole-Cire, Pamela, Gottesfeld, Joel M., Millstein, Larry, Peck, Lawrence J., Varshavsky, Alexander   +4 more
core   +1 more source

Mutagenesis and structural studies reveal the basis for the specific binding of SARS-CoV-2 SL3 RNA element with human TIA1 protein

Nature Communications, 2023
Viral RNA-host protein interactions are indispensable during RNA virus transcription and replication, but their detailed structural and dynamical features remain largely elusive. Here, we characterize the binding interface for the SARS-CoV-2 stem-loop 3 (
Dong Zhang, Lulu Qiao, Xiaobo Lei, Xiaojing Dong, Yunguang Tong, Jianwei Wang, Zhiye Wang, Ruhong Zhou   +7 more
doaj   +1 more source

Heat shock-induced phosphorylation of TAR DNA-binding protein 43 (TDP-43) by MAPK/ERK kinase regulates TDP-43 function [PDF]

, 2017
TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing.
Ayala, Yuna M, Bigio, Eileen H, Fey, Erin E, French, Rachel L, Knoverek, Catherine R, Li, Wen, Lin, Binyan, Reeb, Ashley N, Subramanian, Praveen   +8 more
core   +2 more sources

Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits. [PDF]

, 2017
In prokaryotes, RNA polymerase and ribosomes can bind concurrently to the same RNA transcript, leading to the functional coupling of transcription and translation.
Blaha, Gregor M, Conn, Adam B, Diggs, Stephen, Fan, Haitian, Gamper, Howard B, Hahm, Joseph, Hou, Ya-Ming, O'Leary, Seán E, Wang, Yinsheng, Williams, Preston B   +9 more
core   +1 more source

Characterizing the tumor RBP-ncRNA circuits by integrating transcriptomics, interactomics and clinical data

Computational and Structural Biotechnology Journal, 2021
The interactions among non-coding RNA (ncRNA) and RNA binding protein (RBP) are increasingly recognized as one of basic mechanisms in gene regulation, and play a crucial role in cancer progressions.
Leiming Jiang, Qiuyang Chen, Mingrong Bei, Mengting Shao, Jianzhen Xu   +4 more
doaj   +1 more source

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [PDF]

, 1998
Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.
Baird, Eldon E., Dervan, Peter B., Dickinson, Liliane A., Gottesfeld, Joel M., Gulizia, Richard J., Mosier, Donald E., Trauger, John W.   +6 more
core   +1 more source

Targeting RNA binding protein in prostate cancer

Molecular & Cellular Oncology, 2017
RNA binding protein (RBP) controls multiple aspects of RNA metabolism and plays crucial roles in many physiopathological contexts, including cancer. We recently identified an RBP HNRNPL as a novel prostate cancer dependency via regulation of RNA splicing,
Teng Fei
doaj   +1 more source