Results 41 to 50 of about 2,365,116 (344)
Advances in the characterization of RNA‐binding proteins
WIREs RNA, 2016 From transcription, to transport, storage, and translation, RNA depends on association with different RNA‐binding proteins (RBPs). Methods based on next‐generation sequencing and protein mass‐spectrometry have started to unveil genome‐wide interactions of RBPs but many aspects still remain out of sight.
Domenica Marchese +5 more
openaire +5 more sources
RNA-binding proteins in neurological diseases [PDF]
Science China Life Sciences, 2014 Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylation, transport, surveillance, mRNA localization, mRNA stability control, translational control and editing of various types of RNAs ...
Jianghong Liu +5 more
openaire +4 more sources
Targeting RNA binding protein in prostate cancer
Molecular & Cellular Oncology, 2017 RNA binding protein (RBP) controls multiple aspects of RNA metabolism and plays crucial roles in many physiopathological contexts, including cancer. We recently identified an RBP HNRNPL as a novel prostate cancer dependency via regulation of RNA splicing,
Teng Fei
doaj +1 more source
Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3
Nature Communications, 2019 How multidomain RNA-binding proteins recognize their specific target sequences, based on a combinatorial code, represents a fundamental unsolved question and has not been studied systematically so far.
Tim Schneider +14 more
semanticscholar +1 more source
SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells. [PDF]
PLoS ONE, 2016 The RNA-binding protein La is involved in several aspects of RNA metabolism including the translational regulation of mRNAs and processing of pre-tRNAs.
Venkatesh Kota +6 more
doaj +1 more source
RNA Binding Proteins and Genome Integrity [PDF]
International Journal of Molecular Sciences, 2017 Genome integrity can be threatened by various endogenous or exogenous events. To counteract these stressors, the DNA damage response network contributes to the prevention and/or repair of genomic DNA damage and serves an essential function in cellular survival. DNA binding proteins are involved in this network.
Nishida, Kensei +4 more
openaire +2 more sources
Dissection and prediction of RNA-binding sites on proteins
Biomolecular Concepts, 2010 RNA-binding proteins are involved in many important regulatory processes in cells and their study is essential for a complete understanding of living organisms. They show a large variability from both structural and functional points of view.
Pérez-Cano Laura, Fernández-Recio Juan
doaj +1 more source
The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level
Nature Communications, 2018 The integrity of stratified epithelia depends on the ability of progenitor cells to maintain a balance between proliferation and differentiation.
E. Kwon +10 more
semanticscholar +1 more source
Pharmaceuticals, 2011 Many genetic and infectious diseases can be targeted at the RNA level as RNA is more accessible than DNA. We seek to develop new approaches for detection and tracking RNA in live cells, which is necessary for RNA-based diagnostics and therapy.
Charles R. Cantor +4 more
doaj +1 more source
Genes & Development, 2017 Here, Huang et al. investigated the role of RNA secondary structure in splicing regulation and show that RNA elements with G-quadruplex-forming capacity promote exon inclusion.
Huilin Huang +4 more
semanticscholar +1 more source