Results 61 to 70 of about 2,765,005 (400)

PTRE-seq reveals mechanism and interactions of RNA binding proteins and miRNAs [PDF]

, 2018
A large number of RNA binding proteins (RBPs) and miRNAs bind to the 3′ untranslated regions of mRNA, but methods to dissect their function and interactions are lacking.
Chaudhari, Hemangi G, Cohen, Barak A, Cottrell, Kyle A, Djuranovic, Sergej   +3 more
core   +3 more sources

RNA-Binding Proteins in Cancer: Functional and Therapeutic Perspectives

Cancers, 2020
Simple Summary RNA-binding proteins (RBPs) play central roles in regulating posttranscriptional expression of genes. Many of them are known to be deregulated in a wide variety of cancers.
Donghee Kang, Yerim Lee, Jae-Seon Lee
semanticscholar   +1 more source

RNA Binding Proteins and Genome Integrity [PDF]

International Journal of Molecular Sciences, 2017
Genome integrity can be threatened by various endogenous or exogenous events. To counteract these stressors, the DNA damage response network contributes to the prevention and/or repair of genomic DNA damage and serves an essential function in cellular survival. DNA binding proteins are involved in this network.
Nishida, Kensei, Kuwano, Yuki, Nishikawa, Tatsuya, Masuda, Kiyoshi, Rokutan, Kazuhito   +4 more
openaire   +2 more sources

RNA-Binding Proteins: Splicing Factors and Disease

Biomolecules, 2015
Pre-mRNA splicing is mediated by interactions of the Core Spliceosome and an array of accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory component in higher eukaryotes.
Alger M. Fredericks, Kamil J. Cygan, Brian A. Brown, William G. Fairbrother   +3 more
doaj   +1 more source

RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?

Journal of Extracellular Vesicles, 2020
Extracellular vesicles (EVs) are heterogeneous membranous particles released from the cells through different biogenetic and secretory mechanisms. We now conceive EVs as shuttles mediating cellular communication, carrying a variety of molecules resulting
Fabrizio Fabbiano, J. Corsi, Elena Gurrieri, C. Trevisan, M. Notarangelo, V. D’Agostino   +5 more
semanticscholar   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

An in Vitro Technique to Identify the RNA Binding-Site Sequences for RNA-Binding Proteins [PDF]

BioTechniques, 2017
RNA-protein interactions play a major role in gene regulation. Although many techniques to analyze RNA-protein interactions have been developed, noteworthy challenges such as determining the RNA sequences that bind RNA-binding proteins (RBPs) remain unsolved.
Sunkyung Choi, Kyoon Eon Kim, Chungoo Park, Kee K. Kim   +3 more
openaire   +4 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes [PDF]

, 2018
The different steps of gene expression are intimately linked to coordinate and regulate this complex process. During transcription, numerous RNA-binding proteins are already loaded onto the nascent mRNA and package the mRNA into a messenger ...
Georgieva, Sofia, Hüttelmaier, Stefan, Kopytova, Daria, Minocha, Rashmi, Misiak, Danny, Popova, Varvara, Sträßer, Katja   +6 more
core   +1 more source

Alternative splicing and related RNA binding proteins in human health and disease

Signal Transduction and Targeted Therapy
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein structure and functionality. Across varying tissues, developmental stages, or under specific conditions,
Y. Tao, Qi Zhang, Haoyu Wang, Xiyu Yang, Haoran Mu   +4 more
semanticscholar   +1 more source