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Origin and Evolution of RNA-Dependent RNA Polymerase [PDF]
Frontiers in Genetics, 2017 RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced back from tRNA ancestors.
Ariosvaldo Pereira dos Santos Junior +3 more
doaj +6 more sources
Structure of the RNA-dependent RNA polymerase of poliovirus [PDF]
Structure, 1997 Background: The central player in the replication of RNA viruses is the viral RNA-dependent RNA polymerase. The 53 kDa poliovirus polymerase, together with other viral and possibly host proteins, carries out viral RNA replication in the host cell ...
Hansen, Jeffrey L +2 more
core +5 more sources
RNA-dependent RNA polymerase 1 in potato (Solanum tuberosum) and its relationship to other plant RNA-dependent RNA polymerases [PDF]
Scientific Reports, 2011 Cellular RNA-dependent RNA polymerases (RDR) catalyze synthesis of double stranded RNAs that can serve to initiate or amplify RNA silencing. Arabidopsis thaliana has six RDR genes; RDRs 1, 2 and 6 have roles in anti-viral RNA silencing.
Hunter, Lydia JR +7 more
core +15 more sources
Ubiquitous RNA-dependent RNA polymerase and gene silencing [PDF]
Genome Biology, 2009 The discovery of a ubiquitous RNA-dependent RNA polymerase raises new questions about small RNA silencing ...
Birchler, James A
core +6 more sources
Common and unique features of viral RNA-dependent polymerases. [PDF]
Cellular and Molecular Life Sciences, 2014 Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average, these pathogens share little sequence similarity and use different replication and transcription strategies.
Velthuis, A.J.W. te
core +7 more sources
Reticulocyte RNA-Dependent RNA Polymerase [PDF]
Proceedings of the National Academy of Sciences, 1973 A cytoplasmic, microsomal bound RNA-dependent RNA polymerase has been purified 2500-fold from rabbit reticulocyte lysates. The synthesis of RNA with the purified enzyme is absolutely dependent on the addition of an RNA template. The best template is hemoglobin messenger RNA, while bacteriophage RNA and poly(A,G) are less active, and DNA is completely ...
Antero G. So +3 more
openaire +3 more sources
The Rna-Dependent RNA Polymerase of the Influenza a Virus [PDF]
Future Virology, 2014 The influenza A virus causes a highly contagious respiratory disease that significantly impacts our economy and health. Its replication and transcription is catalyzed by the viral RNA polymerase. This enzyme is also crucial for the virus, because it is involved in the adaptation of zoonotic strains.
Stubbs, T, te Velthuis, A
openaire +3 more sources
Inhibitors of an RNA‐dependent DNA polymerase [PDF]
FEBS Letters, 1971 Much interest of late has centered around RNAdirected DNA synthesis. Initially, with the finding of an RNA-dependent DNA polymerase in oncogenic RNA viruses [l-S] and what was described as the exclusive presence of the polymerase in acute leukemia cells as opposed to ‘normal’ cells [6] , speculation as to a molecular basis for leukemogenesis and a ...
H.Bruce Bosmann, David Kessel
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RNA-dependent RNA polymerase of tobacco plants [PDF]
Proceedings of the National Academy of Sciences, 1978 Several properties of RNA polymerase (nucleosidetriphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) active fractions obtained from tobacco plants, be they uninfected, infected with tobacco mosaic virus, or infected with tobacco necrosis virus, were compared.
H. Fraenkel-Conrat, Machiko Ikegami
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RNA-dependent RNA polymerases of plants [PDF]
Proceedings of the National Academy of Sciences, 1979 The existence of RNA-dependent RNA polymerases (EC 2.7.7.48) in plants has been definitely proven by their isolation in pure form from cucumber and tobacco in our laboratory and from cowpea at Wageningen. These enzymes are single-chain proteins of 100-130 kilodaltons. They show clear physical and biochemical differences characteristic for a given plant
openaire +4 more sources