Results 1 to 10 of about 748,669 (207)

Origin and Evolution of RNA-Dependent RNA Polymerase [PDF]

Frontiers in Genetics, 2017
RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias, Ariosvaldo P. dos Santos Junior, Thais G. Rêgo, Marco V. José   +3 more
doaj   +4 more sources

SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study

Heliyon, 2020
The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one
Jamshaid Ahmad, Saima Ikram, Fawad Ahmad, Irshad Ur Rehman, Maryam Mushtaq   +4 more
doaj   +2 more sources

Molecular evolution and diversity of the norovirus RNA-dependent RNA polymerase [PDF]

Scientific Reports
Human noroviruses (HuNoVs) are the leading cause of non-bacterial gastroenteritis worldwide, exhibiting extensive genetic diversity driven by recombination and mutation.
Annika Flint, Maryam Jawad, Neda Nasheri
doaj   +2 more sources

Discovery of a Novel Non‐Nucleoside Inhibitor of RNA‐Dependent RNA Polymerase Against Dengue Virus [PDF]

MedComm
Dengue virus (DENV) is an acute infectious pathogen worldwide, for which no effective therapeutics are available. The RNA‐dependent RNA polymerase (RdRp) displays an important role during DENV replication and is therefore a promising target in the ...
Xue‐Mei He, Li‐Fang Zou, Jing‐Tao Yu, Tang‐Jia Yang, Zi‐Bin Lu, Hui‐Hui Cao, Wen Li, Bing Chen, Wei Zhao, Jian‐Ping Zuo, Lin‐Zhong Yu, Jun‐Shan Liu   +11 more
doaj   +2 more sources

Structure of the RNA-dependent RNA polymerase P2 from the cystovirus φ8 [PDF]

Scientific Reports
The replication of RNA viruses relies on the activity of RNA-dependent RNA polymerases (RdRps). Despite large variations in their genomic sequences, viral RdRps share a common architecture generally known as a closed right hand.
Merlyn Latimer-Smith, Paula S. Salgado, Ismay Forsyth, Eugene Makeyev, Minna M. Poranen, Dave I. Stuart, Jonathan M. Grimes, Kamel El Omari   +7 more
doaj   +2 more sources

Amentoflavone from Selaginella tamariscina inhibits SARS-CoV-2 RNA-dependent RNA polymerase [PDF]

Heliyon
The SARS-CoV-2 pandemic caused millions of deaths due to its prominent infectivity and mortality. Although the vaccines and medicines for SARS-CoV-2 are on the market, new coronavirus variants like influenza are expected to reemerge continuously ...
Kyoung Won Youn, Siyun Lee, Jang Hoon Kim, Yea-In Park, Jaeyeon So, Chansoo Kim, Chong Woon Cho, Junsoo Park   +7 more
doaj   +2 more sources

Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition

Molecules, 2021
The COVID-19 pandemic has caused millions of fatalities since 2019. Despite the availability of vaccines for this disease, new strains are causing rapid ailment and are a continuous threat to vaccine efficacy.
Shah Faisal, Syed Lal Badshah, Bibi Kubra, Mohamed Sharaf, Abdul-Hamid Emwas, Mariusz Jaremko, Mohnad Abdalla   +6 more
doaj   +1 more source

Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)

Molecules, 2021
An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2.
Yifei Wu, David Crich, Scott D. Pegan, Lei Lou, Madelyn C. Hansen, Carson Booth, Ellison Desrochers, Lauren Nicole Mullininx, Edward B. Starling, Kuan Y. Chang, Zhong-Ru Xie   +10 more
doaj   +1 more source

Identification of 6ω-cyclohexyl-2-(phenylamino carbonylmethylthio)pyrimidin-4(3H)-ones targeting the ZIKV NS5 RNA dependent RNA polymerase

Frontiers in Chemistry, 2022
Zika virus (ZIKV), a mosquito-borne flavivirus, is a global health concern because of its association with severe neurological disorders such as neonatal microcephaly and adult Guillain-Barre syndrome.
Guang-Feng Zhou, Guang-Feng Zhou, Cong-Qiang Xie, Jian-Xia Xue, Jian-Xia Xue, Jing-Bo Wang, Yu-Zhuo Yang, Chang-Bo Zheng, Rong-Hua Luo, Ren-Hua Yang, Wen Chen, Liu-Meng Yang, Yue-Ping Wang, Hong-Bin Zhang, Yan-Ping He, Yong-Tang Zheng   +15 more
doaj   +1 more source

Reticulocyte RNA-Dependent RNA Polymerase [PDF]

Proceedings of the National Academy of Sciences, 1973
A cytoplasmic, microsomal bound RNA-dependent RNA polymerase has been purified 2500-fold from rabbit reticulocyte lysates. The synthesis of RNA with the purified enzyme is absolutely dependent on the addition of an RNA template. The best template is hemoglobin messenger RNA, while bacteriophage RNA and poly(A,G) are less active, and DNA is completely ...
K M, Downey, J J, Byrnes, B S, Jurmark, A G, So   +3 more
openaire   +2 more sources