Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase
Microorganisms, 2021 Coronavirus Disease 2019 (COVID-19) is a deadly emerging infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Because SARS-CoV-2 is easily transmitted through the air and has a relatively long incubation time, COVID ...
Keivan Zandi +14 more
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Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase [PDF]
Nature Communications, 2017 Transcription in all living organisms is accomplished by multi-subunit RNA polymerases (msRNAPs). msRNAPs are highly conserved in evolution and invariably share a B400 kDa five-subunit catalytic core.
Forrest, David +3 more
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Inspection on the mechanism of SARS-CoV-2 inhibition by penciclovir: a molecular dynamic study [PDF]
Molecules, 2023 In recent years, humanity has had to face a critical pandemic due to SARS-CoV-2. In the rapid search for effective drugs against this RNA-positive virus, the repurposing of already existing nucleotide/nucleoside analogs able to stop RNA replication by ...
Giannetti, Micaela +3 more
core +3 more sources
Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
Viruses, 2019 Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses.
Egor P. Tchesnokov +3 more
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Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
Nature Communications, 2017 The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the ...
Andre S. Godoy +6 more
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Model of Transcriptional Activation by MarA in Escherichia coli [PDF]
, 2009 We have developed a mathematical model of transcriptional activation by MarA in Escherichia coli, and used the model to analyze measurements of MarA-dependent activity of the marRAB, sodA, and micF promoters in mar-rob- cells.
Markowitz, David A. +3 more
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Molecular Evolution of RNA-Dependent RNA Polymerase Region in Norovirus Genogroup I. [PDF]
Viruses, 2023 Norovirus is the leading viral agent of gastroenteritis in humans. RNA-dependent RNA polymerase (RdRp) is essential in the replication of norovirus RNA. Here, we present a comprehensive evolutionary analysis of the norovirus GI RdRp gene.
Zhou N, Huang Y, Zhou L, Li M, Jin H.
europepmc +2 more sources
Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition
Molecules, 2021 The COVID-19 pandemic has caused millions of fatalities since 2019. Despite the availability of vaccines for this disease, new strains are causing rapid ailment and are a continuous threat to vaccine efficacy.
Shah Faisal +6 more
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Structure of the RNA-dependent RNA polymerase P2 from the cystovirus φ8. [PDF]
Sci RepThe replication of RNA viruses relies on the activity of RNA-dependent RNA polymerases (RdRps). Despite large variations in their genomic sequences, viral RdRps share a common architecture generally known as a closed right hand.
Latimer-Smith M +7 more
europepmc +2 more sources
Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)
Molecules, 2021 An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2.
Yifei Wu +10 more
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