Results 11 to 20 of about 987,281 (377)

RNA-dependent RNA polymerase 1 in potato (Solanum tuberosum) and its relationship to other plant RNA-dependent RNA polymerases. [PDF]

Scientific Reports, 2016
Cellular RNA-dependent RNA polymerases (RDRs) catalyze synthesis of double-stranded RNAs that can serve to initiate or amplify RNA silencing. Arabidopsis thaliana has six RDR genes; RDRs 1, 2 and 6 have roles in anti-viral RNA silencing.
Brockington, Samuel F, Carr, John P, Gruden, Kristina, Hunter, Lydia JR, MacFarlane, Stuart A, Murphy, Alex M, Palukaitis, Peter, Pate, Adrienne E   +7 more
core   +16 more sources

Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA polymerase [PDF]

Cell Reports
Summary: The Piwi/Piwi-interacting RNA (piRNA) pathway protects genome integrity in animal germ lines. Maturation of piRNAs involves nucleolytic processing at both 5′ and 3′ ends.
Benjamin Pastore, Hannah L. Hertz, Wen Tang   +2 more
doaj   +2 more sources

Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site Inhibition

Molecules, 2021
The COVID-19 pandemic has caused millions of fatalities since 2019. Despite the availability of vaccines for this disease, new strains are causing rapid ailment and are a continuous threat to vaccine efficacy.
Shah Faisal, Syed Lal Badshah, Bibi Kubra, Mohamed Sharaf, Abdul-Hamid Emwas, Mariusz Jaremko, Mohnad Abdalla   +6 more
doaj   +1 more source

Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)

Molecules, 2021
An increasing number of studies have demonstrated the antiviral nature of polyphenols, and many polyphenols have been proposed to inhibit SARS-CoV or SARS-CoV-2.
Yifei Wu, David Crich, Scott D. Pegan, Lei Lou, Madelyn C. Hansen, Carson Booth, Ellison Desrochers, Lauren Nicole Mullininx, Edward B. Starling, Kuan Y. Chang, Zhong-Ru Xie   +10 more
doaj   +1 more source

Identification of 6ω-cyclohexyl-2-(phenylamino carbonylmethylthio)pyrimidin-4(3H)-ones targeting the ZIKV NS5 RNA dependent RNA polymerase

Frontiers in Chemistry, 2022
Zika virus (ZIKV), a mosquito-borne flavivirus, is a global health concern because of its association with severe neurological disorders such as neonatal microcephaly and adult Guillain-Barre syndrome.
Guang-Feng Zhou, Guang-Feng Zhou, Cong-Qiang Xie, Jian-Xia Xue, Jian-Xia Xue, Jing-Bo Wang, Yu-Zhuo Yang, Chang-Bo Zheng, Rong-Hua Luo, Ren-Hua Yang, Wen Chen, Liu-Meng Yang, Yue-Ping Wang, Hong-Bin Zhang, Yan-Ping He, Yong-Tang Zheng   +15 more
doaj   +1 more source

Reticulocyte RNA-Dependent RNA Polymerase [PDF]

Proceedings of the National Academy of Sciences, 1973
A cytoplasmic, microsomal bound RNA-dependent RNA polymerase has been purified 2500-fold from rabbit reticulocyte lysates. The synthesis of RNA with the purified enzyme is absolutely dependent on the addition of an RNA template. The best template is hemoglobin messenger RNA, while bacteriophage RNA and poly(A,G) are less active, and DNA is completely ...
Antero G. So, John J. Byrnes, Bonnie S. Jurmark, Kathleen M. Downey   +3 more
openaire   +3 more sources

SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study

Heliyon, 2020
The outbreak of SARS-CoV-2 in December 2019 in China subsequently lead to a pandemic. Lack of vaccine and specific anti-viral drugs started a global health disaster. For a sustained control and protection, development of potential anti-viral drugs is one
Jamshaid Ahmad, Saima Ikram, Fawad Ahmad, Irshad Ur Rehman, Maryam Mushtaq   +4 more
doaj   +1 more source

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Science, 2020
The COVID-19 RNA-synthesizing machine Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al.
Yan Gao, Liming Yan, Yucen Huang, Fengjiang Liu, Yao Zhao, Lin Cao, Tao Wang, Qianqian Sun, Z. Ming, Lianqi Zhang, Ji Ge, Litao Zheng, Ying Zhang, Haofeng Wang, Yan Zhu, Chen Zhu, T. Hu, T. Hua, Bing Zhang, Xiuna Yang, Jun Li, Haitao Yang, Zhijie Liu, Wenqing Xu, L. Guddat, Quan Wang, Z. Lou, Z. Rao   +27 more
semanticscholar   +1 more source

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

bioRxiv, 2020
The pandemic of Corona Virus Disease 2019 (COVID-19) caused by SARS-CoV-2 has become a global crisis. The replication of SARS-CoV-2 requires the viral RNA-dependent RNA polymerase (RdRp), a direct target of the antiviral drug, Remdesivir.
W. Yin, C. Mao, X. Luan, D. Shen, Q. Shen, H. Su, Xiao-xi Wang, F. Zhou, Wenfeng Zhao, M. Gao, Shenghai Chang, Yuanchao Xie, Guanghui Tian, He-wei Jiang, S. Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shuyang Zhang, Yan Zhang, H. Eric Xu   +21 more
semanticscholar   +1 more source

Mutations in the SARS-CoV-2 RNA dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms

Science Translational Medicine, 2022
The nucleoside analog remdesivir (RDV) is a Food and Drug Administration–approved antiviral for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.
Laura J. Stevens, A. Pruijssers, Hery W. Lee, Calvin J. Gordon, E. Tchesnokov, Jennifer Gribble, Amelia S. George, Tia M. Hughes, Xiaotao Lu, Jiani Li, Jason K. Perry, D. Porter, T. Cihlář, T. Sheahan, R. Baric, M. Götte, M. Denison   +16 more
semanticscholar   +1 more source