Results 51 to 60 of about 1,029,988 (373)
RNA-dependent RNA polymerases of plants [PDF]
Proceedings of the National Academy of Sciences, 1979 The existence of RNA-dependent RNA polymerases (EC 2.7.7.48) in plants has been definitely proven by their isolation in pure form from cucumber and tobacco in our laboratory and from cowpea at Wageningen. These enzymes are single-chain proteins of 100-130 kilodaltons. They show clear physical and biochemical differences characteristic for a given plant
openaire +2 more sources
In vitro RNA-dependent RNA Polymerase Assay Using Arabidopsis RDR6
Bio-Protocol, 2018 RNA-dependent RNA polymerases (RdRPs) in eukaryotes convert single-stranded RNAs into double-stranded RNAs, thereby amplifying small interfering RNAs that play crucial roles in the regulation of development, maintenance of genome integrity and antiviral ...
Kyungmin Baeg +2 more
doaj +1 more source
RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery
SLAS Discovery, 2020 COVID-19 respiratory disease caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global health issue since it emerged in December 2019.
Wei Zhu +5 more
semanticscholar +1 more source
A narnavirus-like element from the trypanosomatid protozoan parasite Leptomonas seymouri [PDF]
, 2016 Genome sequences were determined for a novel RNA virus, Leptomonas seymouri Narna-like virus 1 (LepseyNLV1). A 2.9-kb segment encodes an RNA-dependent RNA polymerase (RdRp), while a smaller 1.5-kb segment showed no database search matches.
Akopyants, Natalia S +3 more
core +2 more sources
Frontiers in Genetics, 2020 BackgroundRNA-dependent RNA polymerase (RdRp) is the key enzyme responsible for the SARS-CoV-2 replication process and catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA, often recognized as good targets for antiviral ...
Shuang Ao +8 more
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Electron Density Analysis of SARS-CoV-2 RNA-Dependent RNA Polymerase Complexes
Molecules, 2021 The work is devoted to the study of the complementarity of the electronic structures of the ligands and SARS-CoV-2 RNA-dependent RNA polymerase. The research methodology was based on determining of 3D maps of electron densities of complexes using an ...
Nadezhda Palko +2 more
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Journal of Physical Chemistry B, 2020 Starting from late 2019, the coronavirus disease 2019 (COVID-19) has emerged as a once-in-a-century pandemic with deadly consequences, which urgently calls for new treatments, cures, and supporting apparatuses.
Leili Zhang, R. Zhou
semanticscholar +1 more source
Coronavirus Cell-Associated RNA-Dependent RNA Polymerase [PDF]
, 1981 Infectious, single-stranded, nonsegmented, polyadenylated, genomic RNA has been demonstrated for the avian infectious bronchitis virus (Lomniczi and Kennedy, 1977; Schochetman et al., 1977), the mouse hepatitis virus (Lai and Stohlman, 1978; Wege et al., 1978), and the transmissible gastroenteritis virus (TGEV) of swine (Brian et al., 1980), three ...
D E, Dennis, D A, Brian
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Selection of single-chain antibodies that specifically interact with vesicular stomatitis virus (VSV) nucleocapsid and inhibit viral RNA synthesis. [PDF]
, 2005 International audienceThe RNA genome of non-segmented negative-strand RNA viruses is completely covered by the nucleoprotein (N) forming a ribonucleoprotein complex, the nucleocapsid.
Cortay, Jean-Claude +2 more
core +3 more sources
Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B
Viruses, 2010 More than 20 years after the identification of the hepatitis C virus (HCV) as a novel human pathogen, the only approved treatment remains a combination of pegylated interferon-α and ribavirin.
Megan H. Powdrill +2 more
doaj +1 more source