RNA-directed DNA polymerase from particles released by normal goose cells [PDF]
Journal of Virology, 1979 Cells from a goose embryo were shown to release particle-associated RNA-directed DNA polymerase and RNase H activities that required the presence of Nonidet P-40 for detection. The particles were not infectious and did not have endogenous DNA synthesis.
Bauer, Georg, Temin, Howard Martin
semanticscholar +6 more sources
Normal human placentas contain RNA-directed DNA polymerase activity like that in viruses. [PDF]
Proceedings of the National Academy of Sciences, 1978 Extracts from over 100 normal human placentas have been examined for RNA-directed DNA polymerase (DNA nucleotidyltransferase, EC 2.7.7.7) activity. More than 80% of these placentas contained this enzyme activity, which banded at a density of 1.15-1.17 g/ml in sucrose.
Jay A. Nelson, Jo-Ann Leong, Jay A. Levy
semanticscholar +6 more sources
Extent of Transcription of Mouse Sarcoma-Leukemia Virus by RNA-Directed DNA Polymerase [PDF]
Proceedings of the National Academy of Sciences, 1974 The DNA product obtained from the endogenous RNA-directed DNA polymerase (deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase, EC 2.7.7.7) reaction of the Moloney sarcoma:leukemia viruses produced by the 78 A-1 cell line was analyzed and characterized.
R. Hamelin +4 more
semanticscholar +6 more sources
Particles with RNA of High Molecular Weight and RNA-Directed DNA Polymerase in Human Brain Tumors [PDF]
Proceedings of the National Academy of Sciences, 1973 We have previously shown that neoplastic cells of human breast cancers, leukemias, lymphomas, and sarcomas contain particles similar to the viruses that have been established as etiologic agents of these diseases in mice. The present paper concerns tumors of the central nervous system for which no suitable animal model or corresponding virus exists ...
W. Cuatico, S. Spiegelman, J. R. Cho
semanticscholar +5 more sources
A Single Subunit from Avian Myeloblastosis Virus with Both RNA-Directed DNA Polymerase and Ribonuclease H Activity [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1973 Two structurally distinct forms of RNA-directed DNA polymerase from avian myeloblastosis virus were resolved by chromatography on phosphocellulose and purified. In addition to RNA-directed DNA polymerase activity, both enzymes had ribonuclease H (RNase H)
Duane P. Grandgenett +2 more
openalex +2 more sources
Unwinding-like activity associated with avian retrovirus RNA-directed DNA polymerase [PDF]
Journal of Virology, 1978 The avian retrovirus RNA-directed DNA polymerase contains an activity that is capable of removing hydrogen bonds from duplex nucleic acid molecules. This "unwinding-like" activity appears to be specific in its action, affecting RNA.DNA and DNA.DNA duplex molecules but not RNA.RNA duplexes.
Anthony J. Faras +3 more
openaire +4 more sources
Relationship Between RNA-directed DNA Polymerase (Reverse Transcriptase) from Human Acute Leukemic Blood Cells and Primate Type-C Viruses [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1974 An RNA-directed DNA polymerase was isolated from the peripheral blood leukocytes of a patient with acute myelomonocytic leukemia by successive purification of a particulate cytoplasmic fraction with endogenous, ribonuclease-sensitive DNA polymerase ...
Robert E. Gallagher +4 more
openalex +2 more sources
Stimulated Normal Human Lymphocytes Contain a Ribonuclease-Sensitive DNA Polymerase Distinct from Viral RNA-Directed DNA Polymerase [PDF]
Proceedings of the National Academy of Sciences, 1972 Ribonuclease-sensitive DNA synthesis is demonstrated in a cytoplasmic particulate fraction of normal human blood lymphocytes stimulated with phytohemagglutinin, but not in unstimulated lymphocytes. DNA polymerase purified from this fraction does not transcribe the heteropolymeric regions of 70S RNA from RNA tumor viruses, thus distinguishing this ...
Marvin S. Reitz +3 more
openaire +4 more sources
Effect of UV Light on RNA-Directed DNA Polymerase Activity of Murine Oncornaviruses [PDF]
Journal of Virology, 1975 The UV inactivation of RNA-directed DNA polymerase activity of Rauscher leukemia virus was shown to be due to damage to the protein. The UV dose resulting in 37% survival of viral polymerase activity at 254 nm was 2.4 × 10 4 to 3.1 × 10 4 ergs/mm 2 .
Gerald G. Lovinger +3 more
openaire +4 more sources
PLoS Genetics, 2020 RNA-directed DNA methylation (RdDM) is a biological process in which non-coding RNA molecules direct the addition of DNA methylation to specific DNA sequences.
Robert M Erdmann, Colette L Picard
doaj +2 more sources