Results 251 to 260 of about 326,612 (309)

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Deciphering the regulatory landscape of enhancer RNAs in health and disease. [PDF]

Signal Transduct Target Ther
Wang Q, Ten Dijke P, Fan C.
europepmc   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

The proteomics of the giant cedratvirus particles reveals unique and shared features with pitho-like viruses. [PDF]

J Virol
Machado TB, Melo-Hanchuk TD, de Azevedo BL, de Aquino ILM, Cortines JR, Marques RE, Abrahão JS.   +6 more
europepmc   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Protocol for validating computationally predicted splice-altering variants using full-length gene reporter assays. [PDF]

STAR Protoc
Lukes ME, Kiianitsa K, Widjaja A, Korvatska O.   +3 more
europepmc   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

PANDA: AND logic-gated RNA sensing enabled by a photo-activated RCA-Argonaute cascade. [PDF]

Chem Sci
Ke X, Fan H, Qu J, Wang J, Wang Y, Xu T, Chen C, Hu C, Hu T.   +8 more
europepmc   +1 more source

The paradox of nuclear miRNAs: Mechanisms, therapeutic potential, and future directions. [PDF]

Noncoding RNA Res
Yang K, Zhang C, Zhao Z, Feng M, Song L, Xu Z.   +5 more
europepmc   +1 more source

nc886 noncoding RNA regulates hepatitis B virus replication via PKR-dependent eIF2α phosphorylation. [PDF]

Front Cell Infect Microbiol
Piracha ZZ, Saeed U.
europepmc   +1 more source