Results 31 to 40 of about 2,998,848 (249)
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Science, 2012 Ditching Invading DNA Bacteria and archaea protect themselves from invasive foreign nucleic acids through an RNA-mediated adaptive immune system called CRISPR (clustered regularly interspaced short palindromic repeats)/CRISPR-associated (Cas).
M. Jinek +5 more
semanticscholar +1 more source
Molecules, 2020 Guanosine- and uridine-rich single-stranded RNA (GU-rich RNA) is an agonist of Toll-like receptor (TLR) 7 and TLR8 and induces strong immune responses. A nanostructured GU-rich RNA/DNA assembly prepared using DNA nanotechnology can be used as an adjuvant
Fusae Komura +4 more
doaj +1 more source
Characterization of RBP9 and RBP10, two developmentally regulated RNA-binding proteins in Trypanosoma brucei [PDF]
Open Biology, 2017 The fate of an mRNA is determined by its interaction with proteins and small RNAs within dynamic complexes called ribonucleoprotein complexes (mRNPs). In Trypanosoma brucei and related kinetoplastids, responses to internal and external signals are mainly
Luis Miguel De Pablos +4 more
doaj +1 more source
Primary Hyperoxaluria Type 1: The First Patient Treated with Lumasiran in Portugal
Revista Portuguesa de Nefrologia e Hipertensão, 2023 Primary hyperoxaluria type 1 is a rare genetic disease caused by mutations in AGXT, leading to an excessive hepatic production of oxalate, resulting in urolithiasis, nephrocalcinosis and chronic kidney disease.
Madalena Almeida Borges +5 more
doaj +1 more source
Transcriptional and phenotypical heterogeneity of Trypanosoma cruzi cell populations [PDF]
Open Biology, 2015 Trypanosoma cruzi has a complex life cycle comprising pools of cell populations which circulate among humans, vectors, sylvatic reservoirs and domestic animals.
Víctor Seco-Hidalgo +2 more
doaj +1 more source
Monomeric CRP regulates inflammatory responses in human intervertebral disc cells
Bone & Joint Research, 2023 Aims: CRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined.
Clara Ruiz-Fernández +10 more
doaj +1 more source
Nature, 2018 RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and throughput1. However, this approach captures only a static snapshot at a point in
G. L. Manno +22 more
semanticscholar +1 more source
Functional differences between protamine preparations for the transfection of mRNA
Drug Delivery, 2020 Protamine is a natural cationic peptide mixture used as a drug for the neutralization of heparin and in formulations of slow-release insulin. In addition, Protamine can be used for the stabilization and delivery of nucleic acids (antisense, small ...
Natalia Teresa Jarzebska +7 more
doaj +1 more source
Structural Diversity of Sense and Antisense RNA Hexanucleotide Repeats Associated with ALS and FTLD
Molecules, 2020 The hexanucleotide expansion GGGGCC located in C9orf72 gene represents the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD).
Tim Božič +4 more
doaj +1 more source
Bone & Joint Research, 2023 Aims: Mechanical stimulation is a key factor in the development and healing of tendon-bone insertion. Treadmill training is an important rehabilitation treatment.
Jindong Tan +9 more
doaj +1 more source