Results 41 to 50 of about 1,314,359 (264)

RNA‐binding proteins and RNA methylation in myeloid cells

Immunological Reviews, 2021
AbstractRNA‐binding proteins (RBPs) regulate all aspects of the life of mRNA transcripts. They are critically important in regulating immune responses, most notably by restraining excessive inflammation that can potentially lead to tissue damage.
Marian Bataclan, Cristina Leoni, Silvia Monticelli   +2 more
openaire   +3 more sources

Targeting RNA binding protein in prostate cancer

Molecular & Cellular Oncology, 2017
RNA binding protein (RBP) controls multiple aspects of RNA metabolism and plays crucial roles in many physiopathological contexts, including cancer. We recently identified an RBP HNRNPL as a novel prostate cancer dependency via regulation of RNA splicing,
Teng Fei
doaj   +1 more source

Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules

Biomolecules, 2020
Spatiotemporal translational regulation plays a key role in determining cell fate and function. Specifically, in neurons, local translation in dendrites is essential for synaptic plasticity and long-term memory formation.
Rie Ohashi, Nobuyuki Shiina
doaj   +1 more source

Chloroplast RNA-binding proteins [PDF]

Current Genetics, 2003
Chloroplast gene expression is regulated by nucleus-encoded factors, which mainly act at the post-transcriptional level. Plastid RNA-binding proteins (RBPs) represent good candidates for mediating these functions. The picture emerging from recent analyses is that of a great number of differentially regulated RBPs, which are organized in distinct ...
openaire   +2 more sources

CircRNAs and RNA-Binding Proteins Involved in the Pathogenesis of Cancers or Central Nervous System Disorders

Non-Coding RNA, 2023
Circular RNAs (circRNAs), a newly recognized group of noncoding RNA transcripts, have established widespread attention due to their regulatory role in cell signaling. They are covalently closed noncoding RNAs that form a loop, and are typically generated
Yuka Ikeda, Sae Morikawa, Moeka Nakashima, Sayuri Yoshikawa, Kurumi Taniguchi, Haruka Sawamura, Naoko Suga, Ai Tsuji, Satoru Matsuda   +8 more
doaj   +1 more source

Beyond RNA-binding domains: determinants of protein–RNA binding

RNA
RNA-binding proteins (RBPs) are composed of RNA-binding domains (RBDs) often linked via intrinsically disordered regions (IDRs). Structural and biochemical analyses have shown that disordered linkers contribute to RNA binding by orienting the adjacent RBDs and also characterized certain disordered repeats that directly contact the RNA.
Zigdon, Inbal, Carmi, Miri, Brodsky, Sagie, Rosenwaser, Zohar, Barkai, Naama, Jonas, Felix   +5 more
openaire   +2 more sources

Advances in the characterization of RNA‐binding proteins

WIREs RNA, 2016
From transcription, to transport, storage, and translation, RNA depends on association with different RNA‐binding proteins (RBPs). Methods based on next‐generation sequencing and protein mass‐spectrometry have started to unveil genome‐wide interactions of RBPs but many aspects still remain out of sight.
Marchese, Domenica, de Groot, Natalia Sanchez, Lorenzo Gotor, Nieves, Livi, Carmen Maria, Tartaglia, Gian G.   +4 more
openaire   +4 more sources

RNA Detection in Live Bacterial Cells Using Fluorescent Protein Complementation Triggered by Interaction of Two RNA Aptamers with Two RNA-Binding Peptides

Pharmaceuticals, 2011
Many genetic and infectious diseases can be targeted at the RNA level as RNA is more accessible than DNA. We seek to develop new approaches for detection and tracking RNA in live cells, which is necessary for RNA-based diagnostics and therapy.
Charles R. Cantor, Natalia E. Broude, Paul Toran, Hung-Wei Yiu, Vadim V. Demidov   +4 more
doaj   +1 more source

Protocol to measure protein-RNA binding using double filter-binding assays followed by phosphorimaging or high-throughput sequencing

STAR Protocols, 2023
Summary: Binding affinity quantitatively describes the strength of a molecular interaction and is reported by the equilibrium dissociation constant (KD).
Joel Vega-Badillo, Phillip D. Zamore, Karina Jouravleva   +2 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source