Results 111 to 120 of about 134,303 (299)

Additional file 1 of A member of the CAP protein superfamily, Hc-CAP-15, is important for the parasitic-stage development of Haemonchus contortus

, 2023
Additional file 1: Table S1. GenBank accession numbers of Hc-CAP-15 and its homologs from 13 nematode species and one non-nematode species used for alignment and phylogenetic analysis. Table S2.
Chunqun Wang (8197170), Hui Liu (33624), Lu Liu (171341), Min Hu (41912), Yifan Wang (380120), Xin Liu (43569), Zhuolin Tao (16848164)   +6 more
core   +1 more source

Artery‐on‐Chip Demonstrates Mechanical and Functional Features of Healthy and Diseased Living Smooth Muscle Tissue

Advanced Functional Materials, EarlyView.
This article details the development of an artery‐on‐chip platform for in vitro arterial disease modeling and therapeutic discovery. It describes the fabrication of a fibrin biomaterial scaffold seeded with iPSC‐derived smooth muscle and endothelial cells, mimicking native artery properties. Two genetic disease models showcase the platform's ability to
Danielle Yarbrough, Roy Chen, Katerina Katsouleas, Jaron Shoemaker, Travis Brady, Tianfang Yu, Jennifer Arthur Ataam, Connor Amelung, Lakshmi Santhanam, Ioannis Karakikes, Sharon Gerecht   +10 more
wiley   +1 more source

Mitochondrial RNA capping: highly efficient 5’-RNA capping with NAD ⁺ and NADH by yeast and human mitochondrial RNA polymerase

, 2018
Abstract Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD + and NADH, using NAD + and NADH as non-canonical initiating nucleotides
Bird, Jeremy G., Basu, Urmimala, Kuster, David, Ramachandran, Aparna, Grudzien-Nogalska, Ewa, Kiledjian, Megerditch, Temiakov, Dmitry, Patel, Smita S., Ebright, Richard H., Nickels, Bryce E.   +9 more
openaire   +1 more source

Noncanonical metabolite RNA caps: Classification, quantification, (de)capping, and function

WIREs RNA, 2022
AbstractThe 5′ cap of eukaryotic mRNA is a hallmark for cellular functions from mRNA stability to translation. However, the discovery of novel 5′‐terminal RNA caps derived from cellular metabolites has challenged this long‐standing singularity in both eukaryotes and prokaryotes.
openaire   +2 more sources

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

RNA-Seq analysis of THP-1 cells treated with CAP.

, 2023
(A) Volcano plot comparing the CAP-treated group with the non-treated group. Red points indicate DEGs, characterized by |log2(FC)| > 1 and p-adj < 0.05.
Rutvi Sanghavi (17200137), Haruka Odagiri (17200131), Takaya Oshita (17200140), Koji Mizutani (4710145), Sayaka Katagiri (4319461), Takanori Iwata (7383152), Yasuo Takeuchi (2323159), Akira Aoki (3710167), Hiroaki Kobayashi (293986), Giri Park (17200134), Katsunori Yoshikawa (834612), Ito Hirasawa (17200128), Akiko Togi (17200143)   +12 more
core   +1 more source

Immunoinflammatory Mechanisms and Biocompatibility of Bioactive Dental Biomaterials: From Fundamental Insights to Clinical Translation

Advanced Healthcare Materials, EarlyView.
Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha, Amanda Paino Santana, Marta Maria Alves Pereira, Mariana Martins Guerreiro, Jose Mauro Granjeiro, Jamil Awad Shibli, Jeroen J. J. P. van den Beucken, Anton Sculean, Rafael Scaf de Molon, Erica Dorigatti de Avila   +9 more
wiley   +1 more source

Conversion of a DNA ligase into an RNA capping enzyme [PDF]

Nucleic Acids Research, 1999
In eukaryotes, newly synthesised mRNA is 'capped' by the addition of GMP to the 5" end by RNA capping enzymes. Recent structural studies have shown that RNA capping enzymes and DNA ligases have similar protein folds, suggesting a conserved catalytic mechanism.
openaire   +2 more sources

hCLE/RTRAF-HSPC117-DDX1-FAM98B: A New Cap-Binding Complex That Activates mRNA Translation

Frontiers in Physiology, 2019
hCLE/C14orf166/RTRAF, DDX1, and HSPC117 are components of cytoplasmic mRNA-transporting granules kinesin-associated in dendrites. They have also been found in cytoplasmic ribosome-containing RNA granules that transport specific mRNAs halted for ...
Alejandra Pazo, Alejandra Pazo, Alicia Pérez-González, Alicia Pérez-González, Juan Carlos Oliveros, Maite Huarte, Juan Pablo Chavez, Juan Pablo Chavez, Amelia Nieto, Amelia Nieto   +9 more
doaj   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source