Results 131 to 140 of about 134,303 (299)

RNA packaging and uncoating in simple single-stranded RNA viruses [PDF]

, 2012
Simple (non-enveloped) small, positive-sense single-stranded RNA viruses infect hosts from all kingdoms of life. However, their assembly and uncoating processes remain poorly understood. For turnip crinkle virus (TCV), 3D reconstructions by cryoelectron
Bakker, Saskia
core  

Isoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP

, 2009
Most human protein-encoding genes contain multiple exons that are spliced together, frequently in alternative arrangements, by the spliceosome. It is established that U1 snRNP is an essential component of the spliceosome, in human consisting of RNA and ...
Nina Morgner, Hernández Helena, Makarov Evgeny M., H. Hernández (7607219), Yutaka Muto, D. P. Krummel (7607234), Helena Hernández, Carol V Robinson, O. V. Makarova (7607222), Robinson, CV, Krummel, DP, Daniel Pomeranz Krummel, Hernandez, H, Evgeny M Makarov, Makarova, OV, Y. Muto (7607231), Olga V Makarova, Robinson Carol V., E. M. Makarov (7607225), N. Morgner (7607228), Makarov, EM, Robinson, Carol, Makarova Olga V., Muto Yutaka, Krummel Daniel Pomeranz, C. V. Robinson (7607237), Morgner, N, Morgner Nina, Muto, Y   +28 more
core   +1 more source

The RNA cap methyltransferases RNMT and CMTR1 co-ordinate gene expression during neural differentiation. [PDF]

Biochem Soc Trans, 2023
Liang S, Almohammed R, Cowling VH.
europepmc   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

A Rare Allele of ST5 From Wild Rice Enhances Salt Tolerance in Rice

Advanced Science, EarlyView.
A novel salt‐tolerance gene ST5W, characterized by a unique 36‐bp promoter insertion, is found exclusively in a small subset of Oryza rufipogon and is absent in cultivated rice. Field trials confirm ST5W significantly enhances rice yield across diverse genetic backgrounds under saline conditions.
Meng Xing, Jingfen Huang, Qiaoling Yuan, Ziyi Yang, Yanyan Wang, Mingchao Zhao, Yamin Nie, Rui Xu, Hongge Qian, Wenxi Chen, Qiaoling Zhang, Qi Du, Leiyue Geng, Yapeng Li, Ziyi Chen, Shizhuang Wang, Like Lou, Haiyuan Peng, Chongke Zheng, Xianzhi Xie, Xiaoming Zheng, Lifang Zhang, Lianguang Shang, Jiaqiang Sun, Qian Qian, Qingwen Yang, Weihua Qiao   +26 more
wiley   +1 more source

A Common Class of Transcripts with 5'-Intron Depletion, Distinct Early Coding Sequence Features, and N1-Methyladenosine Modification [preprint]

, 2018
Introns are found in 5' untranslated regions (5'UTRs) for 35% of all human transcripts. These 5'UTR introns are not randomly distributed: genes that encode secreted, membrane-bound and mitochondrial proteins are less likely to have them.
Roth, Frederick P., Palazzo, Alexander F., Cenik, Can, Chua, Hon Nian, Snyder, Michael P., Singh, Guramrit, Moore, Melissa J., Akef, Abdalla   +7 more
core   +1 more source

Investigation of the guanine quadruplex resolving activity of the DEAH-box RNA helicase RHAU [PDF]

, 2012
Generally depicted as single- or double-stranded molecules, nucleic acids sequences can adopt various forms of stable secondary structures. In particular, guanine-riche sequence of DNA and RNA can form atypical four-stranded helical structures termed G ...
Lattmann, Simon
core   +1 more source

Utility of the new cobas HCV test for viral load monitoring during direct-acting antiviral therapy.

PLoS ONE, 2019
BackgroundThe COBAS AmpliPrep/COBAS TaqMan assay HCV (CAP/CTM) is widely used in clinical routine for HCV testing. Recently, the new cobas HCV test was established for high throughput testing with minimal operator intervention.
Marcus M Mücke, Benjamin Maasoumy, Julia Dietz, Victoria T Mücke, Christian O Simon, Jesse A Canchola, Marcus Cornberg, Ed G Marins, Michael P Manns, Stefan Zeuzem, Heiner Wedemeyer, Christoph Sarrazin, Johannes Vermehren   +12 more
doaj   +1 more source

A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome. [PDF]

Nucleic Acids Res, 2022
Shannon A, Sama B, Gauffre P, Guez T, Debart F, Vasseur JJ, Decroly E, Canard B, Ferron F.   +8 more
europepmc   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source