Results 101 to 110 of about 29,994 (285)
Genome transcription/translation of segmented, negative-strand RNA viruses
, 2011 The requirements for alignment of capped RNA leader sequences along the viral genome during influenza transcription initiation (“cap-snatching”) have long been an enigma.
Geerts-Dimitriadou, C.
core
Advanced Functional Materials, EarlyView.This article details the development of an artery‐on‐chip platform for in vitro arterial disease modeling and therapeutic discovery. It describes the fabrication of a fibrin biomaterial scaffold seeded with iPSC‐derived smooth muscle and endothelial cells, mimicking native artery properties. Two genetic disease models showcase the platform's ability to
Danielle Yarbrough +10 more
wiley +1 more source
Circular RNAs Biogenesis, Regulatory Mechanisms, and Their Future Applications in Laboratory Medicine [PDF]
Journal of Basic Research in Medical SciencesIntroduction: Circular RNAs (circRNAs)- once considered splicing artifacts- are covalently closed RNA molecules generated through back-splicing, lacking 5′ caps and 3′ poly(A) tails, which confers them with remarkable stability.
Maryam Kheiry, Ali Noori-Zadeh
doaj
Ap4A-RNA in IgE activated mast cells
, 2021 Mast cells are tissue resident members of the immune system. They have a wide range of functions and receptors including the FcεRI receptor, which gets activated by binding to IgE bound to an antigen.
Potužník, Jiří František
core
Advanced Healthcare Materials, EarlyView.A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni +7 more
wiley +1 more source
New types of RNA non-canonical caps and their degradation by NudiX enzymes [PDF]
(English) Currently, more than 170 RNA modifications are known in both prokaryotes and eukaryotes, but the role of many of them is not well understood.
Mititelu, Maria Bianca
core +1 more source
Pattern recognition and signaling mechanisms of RIG-I and MDA5
Frontiers in Immunology, 2014 Most organisms rely on innate immune receptors to recognize conserved molecular structures from invading microbes. Two essential innate immune receptors, RIG-I and MDA5, detect viral double-stranded RNA in the cytoplasm.
Stephanie eReikine +2 more
doaj +1 more source
Conversion of a DNA ligase into an RNA capping enzyme [PDF]
Nucleic Acids Research, 1999 In eukaryotes, newly synthesised mRNA is 'capped' by the addition of GMP to the 5" end by RNA capping enzymes. Recent structural studies have shown that RNA capping enzymes and DNA ligases have similar protein folds, suggesting a conserved catalytic mechanism.
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Surface‐host dialogue at the implant interface governs biological fate and osseointegration. Surface physicochemical properties of titanium (Ti) dental implants, including microgrooves, nanopatterns, nanotopography, roughness, and wettability, modulate the initial adsorption of proteins and the formation of a dynamic biointerface.
Daniela Moreira Cunha +9 more
wiley +1 more source
Natural Biomaterials for Osteochondral Repair: From Source to Strategy
Advanced Healthcare Materials, EarlyView.Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu +5 more
wiley +1 more source