Results 31 to 40 of about 1,834,577 (295)
A smart deoxyribozyme-based fluorescent sensor for in vitro detection of androgen receptor mRNA
Beilstein Journal of Organic Chemistry, 2020 Nowadays a variety of biosensors are widely used in different fields, including biomedical diagnostics and self-testing. Nucleic acid-based biosensors are typically applied to detect another nucleic acid, proteins, ions, and several other types of ...
Ekaterina A. Bryushkova +2 more
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Heliyon, 2023 Cuproptosis is a novel form of programmed cell death. The role and mechanism of cuproptosis-related genes in prostate adenocarcinoma have not been fully understood. In this study, a series of bioinformatic analyses were performed.
Shuyuan Xiao, Weiyang Lou
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Bioengineering, 2023 Conserved omicron RNA (COR) is a 40 base long 99.9% conserved sequence in SARS-CoV-2 Omicron variant, predicted to form a stable stem loop, the targeted cleavage of which can be an ideal next step in controlling the spread of variants.
Lindy G. Karrer +4 more
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RNA Cleavage Linked With Ribosomal Action [PDF]
Genetics, 2005 Abstract Ribonuclease LS in Escherichia coli is a potential antagonist of bacteriophage T4. When T4 dmd is mutated, this RNase efficiently cleaves T4 mRNAs and leads to the silencing of late genes, thus blocking T4 growth. We previously found that, when two consecutive ochre codons were placed in the open reading frame of T4 soc, RNase ...
Haruyo, Yamanishi, Tetsuro, Yonesaki
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Evolution of the R2 retrotransposon ribozyme and its self-cleavage site. [PDF]
PLoS ONE, 2013 R2 is a non-long terminal repeat retrotransposon that inserts site-specifically in the tandem 28S rRNA genes of many animals. Previously, R2 RNA from various species of Drosophila was shown to self-cleave from the 28S rRNA/R2 co-transcript by a hepatitis
Danna G Eickbush +2 more
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Nucleic Acids Research, 1987 Using complementary chimeric oligonucleotides containing deoxyribonucleotides and 2'-O-methylribonucleotides (1), enzymatically synthesized RNA (90 mer) were cleaved at a single site with Escherichia coli RNaseH, either at a hairpin loop or at a stem region.
S, Shibahara +5 more
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Cleavage-based signal amplification of RNA [PDF]
Nature Communications, 2013 RNA detection has become an integral part of current biomedical research. Up to now, the reverse transcription-PCR has been the most practical method to detect mRNA targets. However, RNA detection by reverse transcription-PCR requires sophisticated equipment and it is highly sensitive to contamination with genomic DNA.
Yongyun, Zhao, Li, Zhou, Zhuo, Tang
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Pathogens, 2021 Highly pathogenic avian influenza viruses (HPAIVs) with H5 and H7 hemagglutinin (HA) subtypes are derived from their low pathogenic counterparts following the acquisition of multiple basic amino acids in their HA cleavage site. It has been suggested that
Yurie Kida +12 more
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Regulating gene expression in animals through RNA endonucleolytic cleavage
Heliyon, 2018 The expression of any gene must be precisely controlled for appropriate function. This expression can be controlled at various levels. This includes epigenetic regulation through DNA methylation or histone modifications. At the posttranscriptional level,
Karen Gu, Lawrence Mok, Mark M.W. Chong
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Characterization of MazF-Mediated Sequence-Specific RNA Cleavage in Pseudomonas putida Using Massive Parallel Sequencing. [PDF]
PLoS ONE, 2016 Under environmental stress, microbes are known to alter their translation patterns using sequence-specific endoribonucleases that we call RNA interferases. However, there has been limited insight regarding which RNAs are specifically cleaved by these RNA
Tatsuki Miyamoto +4 more
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