Results 21 to 30 of about 806,296 (336)

Inspection on the Mechanism of SARS-CoV-2 Inhibition by Penciclovir: A Molecular Dynamic Study

Molecules, 2022
In recent years, humanity has had to face a critical pandemic due to SARS-CoV-2. In the rapid search for effective drugs against this RNA-positive virus, the repurposing of already existing nucleotide/nucleoside analogs able to stop RNA replication by ...
Micaela Giannetti, Claudia Mazzuca, Giorgio Ripani, Antonio Palleschi   +3 more
doaj   +1 more source

The Functions of RNA-Dependent RNA Polymerases in Arabidopsis [PDF]

The Arabidopsis Book, 2011
One recently identified mechanism that regulates mRNA abundance is RNA silencing, and pioneering work in Arabidopsis thaliana and other genetic model organisms helped define this process. RNA silencing pathways are triggered by either self-complementary fold-back structures or the production of double-stranded RNA (dsRNA) that gives rise to small RNAs (
Brian D. Gregory, Matthew R. Willmann, Matthew W. Endres, Rebecca T. Cook   +3 more
openaire   +3 more sources

Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases [PDF]

BMC Structural Biology, 2003
The eukaryotic RNA-dependent RNA polymerase (RDRP) is involved in the amplification of regulatory microRNAs during post-transcriptional gene silencing. This enzyme is highly conserved in most eukaryotes but is missing in archaea and bacteria. No evolutionary relationship between RDRP and other polymerases has been reported so far, hence the origin of ...
Lakshminarayan M. Iyer, Eugene V. Koonin, L. Aravind   +2 more
openaire   +2 more sources

RNA Editing with Viral RNA-Dependent RNA Polymerase

ACS Synthetic Biology, 2022
RNA editing is currently attracting attention as a method for editing genetic information without injury to the genome. The most common approach to edit RNA sequences involves the induction of an A-to-I change by adenosine deaminase acting on RNA (ADAR). However, this method only allows point editing.
Shinzi Ogasawara, Ai Yamada
openaire   +3 more sources

Independent Inhibition of the Polymerase and Deubiquitinase Activities of the Crimean–Congo Hemorrhagic Fever Virus Full-Length L-Protein

Proceedings, 2020
The Crimean–Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health Organization (WHO) has listed CCHFV as a priority pathogen with an urgent need for enhanced research ...
Egor P. Tchesnokov, Ben A. Bailey-Elkin, Brian L. Mark, Matthias Götte   +3 more
doaj   +1 more source

RNA-Dependent RNA Polymerase from Heterobasidion RNA Virus 6 Is an Active Replicase In Vitro

Viruses, 2021
Heterobasidion RNA virus 6 (HetRV6) is a double-stranded (ds)RNA mycovirus and a member of the recently established genus Orthocurvulavirus within the family Orthocurvulaviridae.
Alesia A. Levanova, Eeva J. Vainio, Jarkko Hantula, Minna M. Poranen   +3 more
doaj   +1 more source

Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance

Microorganisms, 2021
A variety of antiviral treatments for COVID-19 have been investigated, involving many repurposed drugs. Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by nsp12-nsp7-nsp8) has been targeted by numerous inhibitors, e.g., remdesivir ...
Alfredo Mari, Tim Roloff, Madlen Stange, Kirstine K. Søgaard, Erblin Asllanaj, Gerardo Tauriello, Leila Tamara Alexander, Michael Schweitzer, Karoline Leuzinger, Alexander Gensch, Aurélien E. Martinez, Julia Bielicki, Hans Pargger, Martin Siegemund, Christian H. Nickel, Roland Bingisser, Michael Osthoff, Stefano Bassetti, Parham Sendi, Manuel Battegay, Catia Marzolini, Helena M. B. Seth-Smith, Torsten Schwede, Hans H. Hirsch, Adrian Egli   +24 more
doaj   +1 more source

Stochastic resetting in backtrack recovery by RNA polymerases [PDF]

Phys. Rev. E 93, 062411 (2016), 2016
Transcription is a key process in gene expression, in which RNA polymerases produce a complementary RNA copy from a DNA template. RNA polymerization is frequently interrupted by backtracking, a process in which polymerases perform a random walk along the DNA template.
arxiv   +1 more source

RNA-dependent RNA Polymerase Assay for Hepatitis E Virus

Bio-Protocol, 2017
RNA-dependent RNA polymerase (RdRp) is essential for the replication of viral RNA for RNA viruses. It synthesizes the complementary strand of viral genomic RNA, which is used subsequently as a template to generate more copies of viral genome.
Vidya Nair, Saumya Anang, Akriti Srivastava, Milan Surjit   +3 more
doaj   +1 more source

Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase

Nature Communications, 2017
Although all known RNA polymerases have multiple subunits, unrelated single-subunit polymerases have also been described. Here, the authors describe a single-subunit RNA polymerase from the SPβ prophage ofBacillus subtilis, which shares homology to multi-
David Forrest, Katherine James, Yulia Yuzenkova, Nikolay Zenkin   +3 more
doaj   +1 more source