Results 101 to 110 of about 2,110,017 (419)
Arabidopsis chloroplast quantitative editotype [PDF]
, 2013 Chloroplast C-to-U RNA editing is an essential post-transcriptional process. Here we analyzed RNA editing in Arabidopsis thaliana using strand-specific deep sequencing datasets from the wild-type and a mutant defective in RNA 3′ end maturation.
Castandet, Benoit +3 more
core +1 more source
The ADAR Family in Amphioxus: RNA Editing and Conserved Orthologous Site Predictions. [PDF]
, 2020 RNA editing is a relatively unexplored process in which transcribed RNA is modified at specific nucleotides before translation, adding another level of regulation of gene expression. Cephalopods use it extensively to increase the regulatory complexity of
Benito-Gutiérrez, Èlia +5 more
core +3 more sources
RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer [PDF]
, 2022 Most cases of colorectal cancers (CRCs) are microsatellite stable (MSS), which frequently demonstrate lower response rates to immune checkpoint inhibitors (ICIs). RNA editing produces neoantigens by altering amino acid sequences.
Fujiwara, Toshiyoshi +19 more
core +1 more source
FEBS Letters, EarlyView.We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon +5 more
wiley +1 more source
Adenosine‐to‐inosine RNA editing [PDF]
WIREs Systems Biology and Medicine, 2009 AbstractRibonucleic acid (RNA) editing is a mechanism that generates RNA and protein diversity, which is not directly encoded in the genome. The most common type of RNA editing in vertebrates is the conversion of adenosine to inosine in double‐stranded RNA which occurs in the higher eukaryotes.
Kazuko Nishikura, Boris Zinshteyn
openaire +3 more sources
Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies
Molecular Oncology, EarlyView.Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren +16 more
wiley +1 more source
Functions and regulation of RNA editing by ADAR deaminases.
Annual Review of Biochemistry, 2010 One type of RNA editing converts adenosines to inosines (A-->I editing) in double-stranded RNA (dsRNA) substrates. A-->I RNA editing is mediated by adenosine deaminase acting on RNA (ADAR) enzymes.
K. Nishikura
semanticscholar +1 more source
RNA Editing as a Therapeutic Approach for Retinal Gene Therapy Requiring Long Coding Sequences
International Journal of Molecular Sciences, 2020 RNA editing aims to treat genetic disease through altering gene expression at the transcript level. Pairing site-directed RNA-targeting mechanisms with engineered deaminase enzymes allows for the programmable correction of G>A and T>C mutations in RNA ...
L. Fry +4 more
semanticscholar +1 more source
A Comparative Study of the Structural Dynamics of Four Terminal Uridylyl Transferases. [PDF]
, 2017 African trypanosomiasis occurs in 36 countries in sub-Saharan Africa with 10,000 reported cases annually. No definitive remedy is currently available and if left untreated, the disease becomes fatal.
Amaro, Rommie E +2 more
core +1 more source
ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility. [PDF]
, 2020 Adenosine-to-inosine RNA editing, a fundamental RNA modification, is regulated by adenosine deaminase (AD) domain containing proteins. Within the testis, RNA editing is catalyzed by ADARB1 and is regulated in a cell-type dependent manner.
Braun, Robert E +4 more
core +2 more sources