Evolutionarily conserved human targets of adenosine to inosine RNA editing [PDF]
Nucleic Acids Research, Vol. 33, 1162-1168 (2005), 2005 A-to-I RNA editing by ADARs is a post-transcriptional mechanism for expanding the proteomic repertoire. Genetic recoding by editing was so far observed for only a few mammalian RNAs that are predominantly expressed in nervous tissues. However, as these editing targets fail to explain the broad and severe phenotypes of ADAR1 knockout mice, additional ...
arxiv +1 more source
RDDpred: a condition-specific RNA-editing prediction model from RNA-seq data [PDF]
, 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give ...
Benjamin Hur, Min-su Kim, Sun Kim
core +2 more sources
Systematic identification of abundant A-to-I editing sites in the human transcriptome [PDF]
Nature Biotechnology 22, 1001-1005 (2004), 2004 RNA editing by members of the double-stranded RNA-specific ADAR family leads to site-specific conversion of adenosine to inosine (A-to-I) in precursor messenger RNAs. Editing by ADARs is believed to occur in all metazoa, and is essential for mammalian development.
arxiv +1 more source
RNA editing generates cellular subsets with diverse sequence within populations [PDF]
, 2016 RNA editing is a mutational mechanism that specifically alters the nucleotide content in transcribed RNA. However, editing rates vary widely, and could result from equivalent editing amongst individual cells, or represent an average of variable editing ...
Harjanto, D. +5 more
core +1 more source
RNA editing contributes to epitranscriptome diversity in chronic lymphocytic leukemia [PDF]
, 2021 RNA editing—primarily conversion of adenosine to inosine (A > I)—is a widespread posttranscriptional mechanism, mediated by Adenosine Deaminases acting on RNA (ADAR) enzymes to alter the RNA sequence of primary transcripts.
Buchumenski, Ilana +12 more
core +1 more source
Transcriptome analysis identification of A-to-I RNA editing in granulosa cells associated with PCOS
Frontiers in Endocrinology, 2023 BackgroundPolycystic ovary syndrome (PCOS) is a complex, multifactor disorder in women of reproductive age worldwide. Although RNA editing may contribute to a variety of diseases, its role in PCOS remains unclear.MethodsA discovery RNA-Seq dataset was ...
Fan-Sheng Kong +19 more
doaj +1 more source
High Level of Conservation of Mitochondrial RNA Editing Sites Among Four Populus Species
G3: Genes, Genomes, Genetics, 2019 RNA editing occurs in the endosymbiont organelles of higher plants as C-to-U conversions of defined nucleotides. The availability of large quantities of RNA sequencing data makes it possible to identify RNA editing sites and to quantify their editing ...
Wolfram Georg Brenner +7 more
doaj +1 more source
Genome-wide identification of A-to-I RNA editing events provides the functional implications in PDAC
Frontiers in Oncology, 2023 IntroductionRNA editing, a wide-acknowledged post-transcriptional mechanism, has been reported to be involved in the occurrence and development of cancer, especially the abnormal alteration of adenosine to inosine.
Yue Mei +11 more
doaj +1 more source
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]
, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal signaling during development and in maintaining the stability of established networks in the face of altered sensory input.
Ales eBalik +3 more
core +2 more sources
Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development
Nature Communications, 2020 RNA editing and splicing are the two major processes that dynamically regulate human transcriptome diversity. Despite growing evidence of crosstalk between RNA editing enzymes (mainly ADAR1) and splicing machineries, detailed mechanistic explanations and
Sze Jing Tang +13 more
semanticscholar +1 more source