An RNA editing fingerprint of cancer stem cell reprogramming [PDF]
, 2015 BackgroundDeregulation of RNA editing by adenosine deaminases acting on dsRNA (ADARs) has been implicated in the progression of diverse human cancers including hematopoietic malignancies such as chronic myeloid leukemia (CML).
Angela C Court +8 more
core +1 more source
Darned in 2013: inclusion of model organisms and linking with Wikipedia [PDF]
, 2012 DARNED (DAtabase of RNA EDiting, available at http://darned.ucc.ie) is a centralized repository of reference genome coordinates corresponding to RNA nucleotides having altered templated identities in the process of RNA editing.
Baranov, Pavel V. +3 more
core +4 more sources
Transcriptome analysis identification of A-to-I RNA editing in granulosa cells associated with PCOS
Frontiers in Endocrinology, 2023 BackgroundPolycystic ovary syndrome (PCOS) is a complex, multifactor disorder in women of reproductive age worldwide. Although RNA editing may contribute to a variety of diseases, its role in PCOS remains unclear.MethodsA discovery RNA-Seq dataset was ...
Fan-Sheng Kong +19 more
doaj +1 more source
Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver [PDF]
, 2014 BackgroundRNA editing encompasses a post-transcriptional process in which the genomically templated sequence is enzymatically altered and introduces a modified base into the edited transcript. Mammalian C-to-U RNA editing represents a distinct subtype of
Billing, Anja M +11 more
core +3 more sources
Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development
Nature Communications, 2020 RNA editing and splicing are the two major processes that dynamically regulate human transcriptome diversity. Despite growing evidence of crosstalk between RNA editing enzymes (mainly ADAR1) and splicing machineries, detailed mechanistic explanations and
Sze Jing Tang +13 more
semanticscholar +1 more source
Site-directed RNA editing: recent advances and open challenges
RNA Biology, 2021 RNA editing by cytosine and adenosine deaminases changes the identity of the edited bases. While cytosines are converted to uracils, adenines are converted to inosines.
Hamideh Khosravi, M. Jantsch
semanticscholar +1 more source
Genome-wide identification of A-to-I RNA editing events provides the functional implications in PDAC
Frontiers in Oncology, 2023 IntroductionRNA editing, a wide-acknowledged post-transcriptional mechanism, has been reported to be involved in the occurrence and development of cancer, especially the abnormal alteration of adenosine to inosine.
Yue Mei +11 more
doaj +1 more source
Frontiers in Genetics, 2021 Adenosine to inosine (A-to-I) RNA editing, the most prevalent type of RNA editing in metazoans, is carried out by adenosine deaminases (ADARs) in double-stranded RNA regions.
Dean Light +5 more
doaj +1 more source
Combining Insertion and Deletion in RNA-editing Preserves Regularity [PDF]
, 2012 Inspired by RNA-editing as occurs in transcriptional processes in the living cell, we introduce an abstract notion of string adjustment, called guided rewriting. This formalism allows simultaneously inserting and deleting elements.
Bošnački, D. +2 more
core +3 more sources
Improving prime editing with an endogenous small RNA-binding protein
NaturePrime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3′ ends of CRISPR–Cas guide RNAs1.
Jun Yan +18 more
semanticscholar +1 more source