Results 171 to 180 of about 125,592 (278)

Rbm24a dictates mRNA recruitment for germ granule assembly in zebrafish

The EMBO Journal
The germ granules are ribonucleoprotein (RNP) biomolecular condensates that determine the fate of primordial germ cells (PGCs) and serve as a model for studying RNP granule assembly.
Yizhuang Zhang, Jiasheng Wang, Hailing Fang, Shuqi Hu, Boya Yang, Jiayi Zhou, Raphaëlle Grifone, Panfeng Li, Tong Lu, Zhengyang Wang, Chong Zhang, Yubin Huang, Dalei Wu, Qianqian Gong, De-Li Shi, Ang Li, Ming Shao   +16 more
doaj   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source

Germ granule localization of nematode Argonaute WAGO-4 ensures fidelity in small RNA loading

The EMBO Journal
Germ granules are liquid-like condensates that regulate small RNA pathways and gene expression, ensuring genome stability and fertility in animals. In C.
Stela Jelenic, Mathias S Renaud, Samantha Del Borrello, Joseph Gokcezade, Janos Bindics, Lisa Frasz, Philipp Czermak, Peter Duchek, Julie M Claycomb   +8 more
doaj   +1 more source

Biochemical and Immunohistochemical Associations of TDP‐43 and Cryptic RNA With Hippocampal and Amygdala Volumetrics in Alzheimer's Disease

Annals of Neurology, EarlyView.
Objective Immunohistochemically (IHC) measured transactive response DNA‐binding protein 43 (TDP‐43) inclusions are observed in Alzheimer's disease (AD) and are associated with medial temporal lobe atrophy. Accumulation of cryptic exons occurs in AD in response to TDP‐43 pathology.
Hossam Youssef, Rodolfo G. Gatto, Nikhil B. Ghayal, Virginia Estades Ayuso, Karen R. Jansen‐West, Judith A. Dunmore, Yuping Song, Mei Yue, Casey N. Cook, Michael DeTure, Bailey D. Rawlinson, Monica Castanedes‐Casey, Clifford R. Jack Jr, Ronald C. Petersen, Dennis W. Dickson, Leonard Petrucelli, Jennifer L. Whitwell, Mercedes Prudencio, Keith A. Josephs   +18 more
wiley   +1 more source

Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Anke Schmidt, Linus Hübner, Julia van der Linde   +5 more
wiley   +1 more source

Nucleoporins shape germ granule architecture and balance small RNA silencing pathways

Nature Communications
Animals use small RNA pathways, such as PIWI-interacting RNA (piRNA) and small interfering RNA (siRNA), to silence harmful genetic elements. In Caenorhabditis elegans, piRNA pathway components are organized into sub-compartments within germ granules near
Kun Shi, Ying Zhang, Zhenzhen Du, Symonne C. Liu, Ivan Leon, Xinyu Fan, Heng-Chi Lee, Donglei Zhang   +7 more
doaj   +1 more source

Regulation of RNA granules by FMRP and implications for neurological diseases. [PDF]

Traffic, 2020
Lai A, Valdez-Sinon AN, Bassell GJ.
europepmc   +1 more source

HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1

Nature Communications
RNA interference (RNAi) is a conserved gene silencing process that exists in diverse organisms to protect genome integrity and regulate gene expression. In C.
Shihui Chen, Carolyn M. Phillips
doaj   +1 more source

Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics. [PDF]

Nat Cell Biol, 2020
Rey T, Zaganelli S, Cuillery E, Vartholomaiou E, Croisier M, Martinou JC, Manley S.   +6 more
europepmc   +1 more source

Immunodetection of poly(A) binding protein II in the cell nucleus [PDF]

, 1994
Fakan, S., Krause, Sabine, Wahle, E., Weis, K.   +3 more
core   +1 more source