Results 221 to 230 of about 874,898 (240)

Stress granule phase transitions and neuronal fate in cerebral ischemia-reperfusion injury. [PDF]

Front Mol Neurosci
Liao X, Li L, Zhang X, Chen Q, Guo C, Luo J, Wang T, Wang Z.   +7 more
europepmc   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Stress granules formed during infections with RNA viruses have significant virus-specific differences in generation and composition. [PDF]

PLoS Biol
Lang RM, Steiner S, Kelly J, Uldry AC, Dave P, Braga-Lagache S, Chao J, Heller M, Barut GT, Thiel V.   +9 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source

N4BP1 uses tandem KH domains to associate with EDC4 and mRNA decapping factors in P-bodies. [PDF]

Commun Biol
Piłat P, Garg A, Heinemann U, Wilamowski M, Jura J.   +4 more
europepmc   +1 more source

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RNA is required for the integrity of multiple nuclear and cytoplasmic membrane‐less RNP granules

EMBO Journal, 2022
Carolyn J Decker, James Burke, Roy Parker   +2 more
exaly  

Connecting the Dots: Linking Caenorhabditis elegans Small RNA Pathways and Germ Granules

Trends in Cell Biology, 2021
Julie M Claycomb, Ruxandra I Molnar
exaly  

RNA granules

Journal of Cell Biology, 2006
Paul Anderson, Nancy Kedersha
exaly