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Viral sensing by RNA helicases

Virologie, 2020
A key aspect of antiviral immunity is the distinction between "self" and "non-self" components. This distinction can be established through the detection of double-stranded RNA (dsRNA), a common sign of viral infection, by cytosolic RNA helicases.
Claire, Rousseau, Carine, Meignin
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An RNA helicase swirls in lymphangiogenesis

Nature Cell Biology, 2021
How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.
Severin Mühleder, Rui Benedito
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From RNA helicases to RNPases

Trends in Biochemical Sciences, 2001
In eukaryotic cells, all aspects of cellular RNA metabolism require putative RNA helicases of the DEAD and DExH protein families (collectively known as DExD/H families). Based on data from biochemical studies of a few of these RNA helicases, they are generally considered to be involved in the unwinding of duplex RNA molecules.
P, Linder, N K, Tanner, J, Banroques
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Plant RNA helicases: linking aberrant and silencing RNA

Trends in Plant Science, 2009
RNA helicases are ATPases that are capable of rearranging RNA and ribonucleoprotein (RNP) structure, and they can potentially function in any aspect of RNA metabolism. The RNA helicase gene family of plant genomes is larger and more diverse than genome families observed in other systems and provides an ideal model for investigation of the physiological
Linder, Patrick, Owttrim, George
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RNA helicases: modulators of RNA structure

Trends in Cell Biology, 1994
RNA molecules play an essential role in many cellular processes, often as components of ribonucleoprotein complexes. Like proteins, RNA molecules adopt sequence-specific secondary and tertiary structures that are essential for function; alteration of these structures therefore provides a means of regulating RNA function.
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RNA Helicases: Versatile ATP-Driven Nanomotors

Journal of Nanoscience and Nanotechnology, 2005
RNA helicases are a large family of molecular motors that utilize nucleoside triphosphates to unwind RNA duplexes and to remodel RNA protein complexes. In this review, we discuss the structure and function of RNA helicases with an emphasis on the potential application of these enzymes to control conformational changes in nanoassemblies that contain RNA.
Eckhard, Jankowsky   +2 more
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RNA Helicases

2010
RNA helicases and RNA helicase-like proteins are the largest group of enzymes in eukaryotic RNA metabolism and although they are subject to intense ongoing research there is much confusion about function and classification of these enzymes. Although these enzymes are essential for virtually all processes involving RNA, there is no overview detailing ...
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