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The RNA helicase DHX35 functions as a co-sensor for RIG-I-mediated innate immunity. [PDF]

open access: yesPLoS Pathog
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europepmc   +1 more source
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Viral sensing by RNA helicases

Virologie, 2020
A key aspect of antiviral immunity is the distinction between "self" and "non-self" components. This distinction can be established through the detection of double-stranded RNA (dsRNA), a common sign of viral infection, by cytosolic RNA helicases.
Claire, Rousseau, Carine, Meignin
openaire   +3 more sources

An RNA helicase swirls in lymphangiogenesis

Nature Cell Biology, 2021
How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.
Severin Mühleder, Rui Benedito
openaire   +2 more sources

Perturbations of RNA helicases in cancer

WIREs RNA, 2013
AbstractHelicases are implicated in most stages of the gene expression pathway, ranging from DNA replication, RNA transcription, splicing, RNA transport, ribosome biogenesis, mRNA translation, RNA storage and decay. These enzymes utilize energy derived from nucleotide triphosphate hydrolysis to remodel ribonucleoprotein complexes, RNA, or DNA and in ...
Francis, Robert, Jerry, Pelletier
openaire   +2 more sources

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