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Perturbations of RNA helicases in cancer
WIREs RNA, 2013AbstractHelicases are implicated in most stages of the gene expression pathway, ranging from DNA replication, RNA transcription, splicing, RNA transport, ribosome biogenesis, mRNA translation, RNA storage and decay. These enzymes utilize energy derived from nucleotide triphosphate hydrolysis to remodel ribonucleoprotein complexes, RNA, or DNA and in ...
Francis, Robert, Jerry, Pelletier
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RNA helicases: regulators of differentiation
Clinical Biochemistry, 2005RNA helicases are highly conserved enzymes that utilize the energy derived from NTP hydrolysis to modulate the structure of RNA. RNA helicases participate in all biological processes that involve RNA, including transcription, splicing and translation. Based on the sequence of the helicase domain, they are classified into families, such as DDX and DHX ...
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The Protein Family of RNA Helicases
Critical Reviews in Biochemistry and Molecular Biology, 1998RNA helicases represent a large family of proteins that have been detected in almost all biological systems where RNA plays a central role. They are ubiquitously distributed over a wide range of organisms and are involved in nuclear and mitochondrial splicing processes, RNA editing, rRNA processing, translation initiation, nuclear mRNA export, and mRNA
A, Lüking, U, Stahl, U, Schmidt
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Helicase associated 2 domain is essential for helicase activity of RNA helicase A
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2014RNA helicase A (RHA), a DExD/H box protein, plays critical roles in a wide variety of cellular or viral functions. RHA contains a conserved core helicase domain that is flanked by five other domains. Two double-stranded RNA binding domains (dsRBD1 and dsRBD2) are at the N-terminus, whereas HA2 (helicase associated 2), OB-fold (oligonucleotide- or ...
Li, Xing +3 more
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Happy Birthday: 30 Years of RNA Helicases
2020RNA helicases are ubiquitous, highly conserved RNA-binding enzymes that use the energy derived from the hydrolysis of nucleoside triphosphate to modify the structure of RNA molecules and/or the functionality of ribonucleoprotein complexes. Ultimately, the action of RNA helicases results in changes in gene expression that allow the cell to perform ...
Valentini, Martina, Linder, Patrick
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Molecular Characterization of Nuclear DNA Helicase II (RNA Helicase A)
2009Nuclear DNA helicase II (NDH II) was first isolated from calf thymus using a DNA-unwinding assay. Subsequently it has been shown to be a homologue of human RNA helicase A (RHA) and the maleless protein (MLE) from Drosophila. Accordingly, the protein possesses both DNA and RNA unwinding activities.
Suisheng, Zhang, Frank, Grosse
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RNA Unwinding Assay for DExD/H-Box RNA Helicases
2004The evolutionarily conserved DExD/H-box proteins are essential for all RNA-related biological processes. They are thought to modulate the structure and function of specific RNAs and/or ribonucleoprotein particles by using their intrinsic RNA-dependent ATPase activities to achieve the desired conformational changes.
Stephanie S, Tseng-Rogenski +1 more
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Cellular functions of eukaryotic RNA helicases and their links to human diseases
Nature Reviews Molecular Cell Biology, 2023Katherine E Bohnsack +2 more
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