Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer [PDF]
Frontiers in Oncology, 2023 Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng +4 more
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Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12 [PDF]
Brazilian Journal of Medical and Biological Research, 2001 DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension
A.A. Camargo +6 more
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Genome-wide systematic survey and analysis of the RNA helicase gene family and their response to abiotic stress in sweetpotato [PDF]
BMC Plant BiologySweetpotato (Ipomoea batatas (L.) Lam.) holds a crucial position as one of the staple foods globally, however, its yields are frequently impacted by environmental stresses.
Fangfang Mu +6 more
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RNA Helicase A Mediates Association of CBP with RNA Polymerase II [PDF]
Cell, 1997 Toshihiro Nakajima +6 more
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Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts [PDF]
Frontiers in Cell and Developmental BiologyIntroductionBurkitt Lymphoma (BL), an aggressive B-cell lymphoma driven by MYC translocations, requires intensive chemotherapy treatments which deliver high effectiveness yet increase future risks of developing secondary malignancies.
Hugues Beauchemin +9 more
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Molecules, 2020 This short review is focused on enzymatic properties of human ATP-dependent RNA helicase DDX3 and the development of antiviral and anticancer drugs targeting cellular helicases.
Marina K. Kukhanova +2 more
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RNA helicase: a novel activity associated with a protein encoded by a positive strand RNA virus
Nucleic Acids Research, 1990 Sonia Laı́n +2 more
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LGP2 plays a critical role in sensitizing mda-5 to activation by double-stranded RNA. [PDF]
, 2013 The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I ...
A Komuro +41 more
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Genome-wide comparative in silico analysis of the RNA helicase gene family in Zea mays and Glycine max: a comparison with Arabidopsis and Oryza sativa. [PDF]
PLoS ONE, 2013 RNA helicases are enzymes that are thought to unwind double-stranded RNA molecules in an energy-dependent fashion through the hydrolysis of NTP. RNA helicases are associated with all processes involving RNA molecules, including nuclear transcription ...
Ruirui Xu +3 more
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RNA Helicase A Regulates the Replication of RNA Viruses
Viruses, 2021 The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell.
Rui-Zhu Shi, Yuan-Qing Pan, Li Xing
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