RNA Helicase A Regulates the Replication of RNA Viruses [PDF]
Viruses, 2021 The RNA helicase A (RHA) is a member of DExH-box helicases and characterized by two double-stranded RNA binding domains at the N-terminus. RHA unwinds double-stranded RNA in vitro and is involved in RNA metabolisms in the cell.
Rui-Zhu Shi, Yuan-Qing Pan, Li Xing
doaj +3 more sources
The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity [PDF]
iScience, 2020 Summary: Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various diseases.
Maria J. Marcaida +8 more
doaj +3 more sources
Genome-wide systematic survey and analysis of the RNA helicase gene family and their response to abiotic stress in sweetpotato [PDF]
BMC Plant BiologySweetpotato (Ipomoea batatas (L.) Lam.) holds a crucial position as one of the staple foods globally, however, its yields are frequently impacted by environmental stresses.
Fangfang Mu +6 more
doaj +2 more sources
Inhibiting the RNA helicase DDX3X in Burkitt lymphoma induces oxydative stress and impedes tumor progression in xenografts [PDF]
Frontiers in Cell and Developmental BiologyIntroductionBurkitt Lymphoma (BL), an aggressive B-cell lymphoma driven by MYC translocations, requires intensive chemotherapy treatments which deliver high effectiveness yet increase future risks of developing secondary malignancies.
Hugues Beauchemin +9 more
doaj +2 more sources
DNA binding of an RNA helicase bacterial transcription terminator. [PDF]
Biochem JJain S, Behera A, Sen R.
europepmc +3 more sources
Genome-wide comparative in silico analysis of the RNA helicase gene family in Zea mays and Glycine max: a comparison with Arabidopsis and Oryza sativa. [PDF]
PLoS ONE, 2013 RNA helicases are enzymes that are thought to unwind double-stranded RNA molecules in an energy-dependent fashion through the hydrolysis of NTP. RNA helicases are associated with all processes involving RNA molecules, including nuclear transcription ...
Ruirui Xu +3 more
doaj +1 more source
Viruses, 2022 Dengue virus replicates its single-stranded RNA genome in membrane-bound complexes formed on the endoplasmic reticulum, where viral non-structural proteins (NS) and RNA co-localize.
Satyamurthy Kundharapu +1 more
doaj +1 more source
Structural basis of the T4 bacteriophage primosome assembly and primer synthesis
Nature Communications, 2023 The T4 bacteriophage gp41 helicase and gp61 primase assemble into a primosome to couple DNA unwinding with RNA primer synthesis for DNA replication. How the primosome is assembled and how the primer length is defined are unclear.
Xiang Feng +4 more
doaj +1 more source
HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete. [PDF]
PLoS Pathogens, 2013 The Lyme disease spirochete Borrelia burgdorferi must differentially express genes and proteins in order to survive in and transit between its tick vector and vertebrate reservoir. The putative DEAH-box RNA helicase, HrpA, has been recently identified as
Aydan Salman-Dilgimen +4 more
doaj +1 more source
RNA helicase domains of viral origin in proteins of insect retrotransposons: possible source for evolutionary advantages [PDF]
PeerJ, 2017 Recently, a novel phenomenon of horizontal gene transfer of helicase-encoding sequence from positive-stranded RNA viruses to LINE transposons in insect genomes was described.
Sergey Y. Morozov +2 more
doaj +2 more sources