Results 91 to 100 of about 342,007 (314)

The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction. [PDF]

, 2018
PINA is a novel ATPase and DNA helicase highly conserved in Archaea, the third domain of life. The PINA from Sulfolobus islandicus (SisPINA) forms a hexameric ring in crystal and solution.
Ahmad, Sohail, DuPrez, Kevin, Fan, Li, Gu, Lichuan, Han, Xiaoyun, Ni, Jinfeng, Shen, Yulong, Xu, Cheng, Yuan, Zenglin, Zhai, Binyuan   +9 more
core   +1 more source

Structural and Functional Studies of Chikungunya Virus nsP2

Proceedings, 2020
Chikungunya virus (CHIKV) is transmitted to humans through mosquitoes and causes Chikungunya fever. Nonstructural protein 2 (nsP2) contains an N-terminal RNA helicase with both nucleotide triphosphatase and RNA triphosphatase activities, and a C-terminal
Yee Song Law, Yaw Bia Tan, Orion Shih, Age Utt, Jie Zheng, Sainan Wang, Ming Wei Chen, Patrick R. Griffin, U-Ser Jeng, Andres Merits, Dahai Luo   +10 more
doaj   +1 more source

High Levels of DEAH-Box Helicases Relate to Poor Prognosis and Reduction of DHX9 Improves Radiosensitivity of Hepatocellular Carcinoma

Frontiers in Oncology, 2022
BackgroundLiver hepatocellular carcinoma (LIHC), one of the most common primary malignancies, exhibits high levels of molecular and clinical heterogeneity.
Xi Chen, Xi Chen, Xi Chen, Letao Lin, Letao Lin, Letao Lin, Guanyu Chen, Guanyu Chen, Guanyu Chen, Huzheng Yan, Zhenyu Li, Zhenyu Li, Meigui Xiao, Meigui Xiao, Meigui Xiao, Xu He, Fujun Zhang, Fujun Zhang, Fujun Zhang, Yanling Zhang, Yanling Zhang, Yanling Zhang, Yanling Zhang   +22 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Flap Endonuclease Disengages Dna2 Helicase/Nuclease from Okazaki Fragment Flaps [PDF]

, 2006
Okazaki fragments contain an initiator RNA/DNA primer that must be removed before the fragments are joined. In eukaryotes, the primer region is raised into a flap by the strand displacement activity of DNA polymerase {delta}.
Bambara, Robert A., Campbell, Judith L., Stewart, Jason A.   +2 more
core   +1 more source

Monitoring helicase activity with molecular beacons

BioTechniques, 2008
A high-throughput, fluorescence-based helicase assay using molecular beacons is described. The assay is tested using the NS3 helicase encoded by the hepatitis C virus (HCV) and is shown to accurately monitor helicase action on both DNA and RNA.
Craig A. Belon, David N. Frick
doaj   +1 more source

DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection

Frontiers in Cellular and Infection Microbiology, 2021
Previous studies have shown that DEAD (Asp-Glu-Ala-Asp)-box RNA helicases play important roles in viral infection, either as cytosolic sensors of pathogenic molecules or as essential host factors against viral infection.
Rui Zhang, Min Cheng, Bingxin Liu, Meng Yuan, Deyan Chen, Yujiong Wang, Zhiwei Wu, Zhiwei Wu, Zhiwei Wu, Zhiwei Wu   +9 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication. [PDF]

, 2013
Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways.
Chan, Winnie M, Liu, Jia, McFadden, Grant, Rahman, Masmudur M, Rothenburg, Stefan   +4 more
core   +1 more source

RNA helicase A is not required for RISC activity

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
It has been shown that siRNAs can compete with each other or with endogenous miRNAs for RISC components. This competition may complicate the interpretations of phenotypes observed through siRNA-mediated knockdown of genes, especially those genes implicated in the RISC pathway.
Liang, Xue-hai, Crooke, Stanley T.
openaire   +2 more sources