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Regulation and mechanisms of action of RNA helicases
RNA BiologyRNA helicases are an evolutionary conserved class of nucleoside triphosphate dependent enzymes found in all kingdoms of life. Their cellular functions range from transcription regulation up to maintaining genomic stability and viral defence.
Nina Lang +2 more
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Redox-Regulated RNA Helicase Expression [PDF]
Plant Physiology, 2000 Abstract In photosynthetic organisms it is becoming increasingly evident that light-driven shifts in redox potential act as a sensor that initiates alterations in gene expression at both the level of transcription and translation. This report provides evidence that the expression of a cyanobacterial RNA helicase gene,crhR, is controlled ...
Sonya L. Kujat, George W. Owttrim
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RNA Helicase Participates in the Editing Game [PDF]
Neuron, 2000 Peter H. Seeburg
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RNA helicases in RNA decay [PDF]
Biochemical Society Transactions, 2018 RNA molecules have the tendency to fold into complex structures or to associate with complementary RNAs that exoribonucleases have difficulties processing or degrading. Therefore, degradosomes in bacteria and organelles as well as exosomes in eukaryotes have teamed-up with RNA helicases.
Khemici, Vanessa, Linder, Patrick
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RNA helicases in bacteria [PDF]
Current Opinion in Microbiology, 2016 RNA plays a crucial role in the control of bacterial gene expression, either as carrier of information or as positive or negative regulators. Moreover, the machinery to decode the information, the ribosome, is a large ribonucleoprotein complex composed of rRNAs and many proteins.
Khemici Vanessa, Linder Patrick
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The RNA helicase database [PDF]
Nucleic Acids Research, 2010 RNA helicases are ubiquitous and essential enzymes that function in nearly all aspects of RNA metabolism. The RNA helicase database (www.rnahelicase.org) integrates the wealth of accumulating information on RNA helicases in a readily accessible format.
Anja Jankowsky +2 more
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RNA helicases in splicing [PDF]
RNA Biology, 2013 In eukaryotic cells, introns are spliced from pre-mRNAs by the spliceosome. Both the composition and the structure of the spliceosome are highly dynamic, and eight DExD/H RNA helicases play essential roles in controlling conformational rearrangements. There is evidence that the various helicases are functionally and physically connected with each other
Jean D. Beggs, Olivier Cordin
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RNA Helicases on the Move [PDF]
Biophysical Journal, 2014 We have investigated the mechanical properties of the RNA-helicase-motor proteins in single-molecule assays using Magnetic Tweezers. RNA helicases are fundamental molecular motors that remodel RNA structures, DNA/RNA hybrids and RNA-protein complexes that are essential in gene regulation.
Francesca Fiorini +6 more
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RNA Chaperones, RNA Annealers and RNA Helicases [PDF]
RNA Biology, 2007 RNA molecules face difficulties when folding into their native structures. In the cell, proteins can assist RNAs in reaching their functionally active states by binding and stabilizing a specific structure or, in a quite opposite way, by interacting in a non-specific manner. These proteins can either facilitate RNA-RNA interactions in a reaction termed
Michael F. Jantsch +9 more
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RNA remodeling by hexameric RNA helicases [PDF]
RNA Biology, 2010 The unwinding of RNA helices and the disruption of RNA-protein complexes are critical steps of cellular metabolism that are carried out by ubiquitous NTP-dependent enzymes named RNA helicases. Here, we review the structures, mechanisms, and biochemical properties of two RNA helicases known to adopt a homo-hexameric ring architecture: the P4 packaging ...
Makhlouf Rabhi +2 more
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