Results 11 to 20 of about 92,282 (271)
eLife, 2014 How different helicase families with a conserved catalytic ‘helicase core’ evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear.
Anna L Mallam +2 more
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The RNA helicase DDX5 is a reprogramming roadblock [PDF]
Stem Cell Investigation, 2017 The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is a major challenge for medical applications such as regenerative medicine since iPSCs can be used to generate different types of functional differentiated cells. Up to now, strategies aiming at reprogramming somatic cells have been mainly conducted toward the targeting of ...
Cyril F. Bourgeois, Didier Auboeuf
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Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing [PDF]
Nucleic Acids Research, 2014 Helicases contribute to diverse biological processes including replication, transcription and translation. Recent reports suggest that unwinding of some helicases display repetitive activity, yet the functional role of the repetitiveness requires further investigation.
Koh, Hye Ran +3 more
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A Cold Shock-Induced Cyanobacterial RNA Helicase [PDF]
Journal of Bacteriology, 1999 ABSTRACT The ability to modify RNA secondary structure is crucial for numerous cellular processes. We have characterized two RNA helicase genes, crhB and crhC , which are differentially expressed in the cyanobacterium Anabaena sp. strain PCC 7120.
Owttrim, George W. +3 more
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DbpA is a region‐specific RNA helicase [PDF]
Biopolymers, 2016 AbstractDbpA is a DEAD‐box RNA helicase implicated in RNA structural rearrangements in the peptidyl transferase center. DbpA contains an RNA binding domain, responsible for tight binding of DbpA to hairpin 92 of 23S ribosomal RNA, and a RecA‐like catalytic core responsible for double‐helix unwinding. It is not known if DbpA unwinds only the RNA helices
Moore, Anthony F.T. +2 more
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Domain Structure of Human Nuclear DNA Helicase II (RNA Helicase A) [PDF]
Journal of Biological Chemistry, 1997 Full-length human nuclear DNA helicase II (NDH II) was cloned and overexpressed in a baculovirus-derived expression system. Recombinant NDH II unwound both DNA and RNA. Limited tryptic digestion produced active helicases with molecular masses of 130 and 100 kDa. The 130-kDa helicase missed a glycine-rich domain (RGG-box) at the carboxyl terminus, while
S, Zhang, F, Grosse
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Nuclear DNA Helicase II/RNA Helicase A Binds to Filamentous Actin [PDF]
Journal of Biological Chemistry, 2002 Nuclear DNA helicase II (NDH II), also designated RNA helicase A, is a multifunctional protein involved in transcription, RNA processing, and transport. Here we report that NDH II binds to F-actin. NDH II was partially purified from HeLa nuclear extracts by ion-exchange chromatography on Bio-Rex 70 and DEAE-Sepharose. Upon gel-filtration chromatography
Suisheng, Zhang +5 more
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The EuroBiotech Journal, 2022 The pathogenic RNA virus that infects human beings contains the RNA helicase enzyme, responsible for the replication of the viral genome. The enzyme is used as a suitable target against which the drug molecule acts.
Satpathy R, Acharya S
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Role and therapeutic potential of DEAD-box RNA helicase family in colorectal cancer
Frontiers in Oncology, 2023 Colorectal cancer (CRC) is the third most commonly diagnosed and the second cancer-related death worldwide, leading to more than 0.9 million deaths every year. Unfortunately, this disease is changing rapidly to a younger age, and in a more advanced stage
Bichun Zheng +4 more
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P68 RNA helicase is a nucleocytoplasmic shuttling protein [PDF]
Cell Research, 2009 P68 RNA helicase is a prototypical DEAD box RNA helicase. The protein plays a very important role in early organ development and maturation. Consistent with the function of the protein in transcriptional regulation and pre-mRNA splicing, p68 was found to predominately localize in the cell nucleus.
Wang, Haizhen +4 more
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