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RNA helicases in infection and disease [PDF]
RNA Biology, 2012 RNA helicases unwind their RNA substrates in an ATP-dependent reaction, and are central to all cellular processes involving RNA. They have important roles in viral life cycles, where RNA helicases are either virus-encoded or recruited from the host. Vertebrate RNA helicases sense viral infections, and trigger the innate antiviral immune response.
Steimer Lenz, Klostermeier Dagmar
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The EuroBiotech Journal, 2022 The pathogenic RNA virus that infects human beings contains the RNA helicase enzyme, responsible for the replication of the viral genome. The enzyme is used as a suitable target against which the drug molecule acts.
Satpathy R, Acharya S
doaj +1 more source
Identification of Five Putative Yeast RNA Helicase Genes [PDF]
, 1990 The RNA helicase gene family encodes a group of eight homologous proteins that share regions of sequence similarity. This group of evolutionarily conserved proteins presumably all utilize ATP (or some other nucleoside triphosphate) as an energy source ...
Abelson, John +2 more
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Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera [PDF]
, 2013 DEAD box helicases catalyze the ATP-dependent destabilization of RNA duplexes. Whereas duplex separation is mediated by the helicase core shared by all members of the family, flanking domains often contribute to binding of the RNA substrate.
Klostermeier, Dagmar +5 more
core +1 more source
RNA Unwinding by the Trf4/Air2/Mtr4 Polyadenylation (TRAMP) Complex [PDF]
, 2012 Many RNA-processing events in the cell nucleus involve the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex, which contains the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.
Anderson, James T. +3 more
core +2 more sources
Indonesian Journal of Pharmacy, 2015 Hepatitis C virus is one of the causative agents for HCV-related liver disease development with high virulence. Antiviral drugs can be discovered through molecular target-based therapy by finding the inhibitors for RNA helicase that play crucial role in ...
Apon Zaenal Mustopa +6 more
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Acta Crystallographica Section A Foundations of Crystallography, 2002 Ido Sagi, Arnon Henn, Barak Akabayov
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PLoS Pathogens, 2020 Positive-stranded (+)RNA viruses greatly exploit host cells to support viral replication. However, unlike many other pathogens, (+)RNA viruses code for only a limited number of genes, making them highly dependent on numerous co-opted host factors for ...
Cheng-Yu Wu, Peter D Nagy
doaj +1 more source
Identification and characterization of the RNA helicase activity of Japanese encephalitis virus NS3 protein [PDF]
, 2000 The NS3 protein of Japanese encephalitis virus (JEV) contains motifs typical of RNA helicase/NTPase but no RNA helicase activity has been reported for this protein.
Akira Igarashi +41 more
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Methotrexate, an anti-inflammatory drug, inhibits Hepatitis E viral replication
Journal of Enzyme Inhibition and Medicinal Chemistry, 2023 Hepatitis E Virus (HEV) is a positively oriented RNA virus having a 7.2 kb genome. HEV consists of three open reading frames (ORF1-3). Of these, ORF1 codes for the enzymes Methyltransferase (Mtase), Papain-like cysteine protease (PCP), RNA helicase, and ...
Akash Kumar +7 more
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