Results 21 to 30 of about 92,282 (271)

Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export [PDF]

The EMBO Journal, 1998
The DBP5 gene encodes a putative RNA helicase of unknown function in the yeast Saccharomyces cerevisiae. It is shown here that Dbp5p is an ATP-dependent RNA helicase required for polyadenylated [poly(A)+] RNA export. Surprisingly, Dbp5p is present predominantly, if not exclusively, in the cytoplasm, and is highly enriched around the nuclear envelope ...
S S, Tseng, P L, Weaver, Y, Liu, M, Hitomi, A M, Tartakoff, T H, Chang   +5 more
openaire   +2 more sources

RNA helicase A is essential for normal gastrulation [PDF]

Proceedings of the National Academy of Sciences, 1998
RNA helicase A (RHA) is the human homologue of the Drosophila maleless protein, an essential factor for the development of male flies. Recently, it was shown that RHA cooperates with the cAMP-responsive element in mediating the cAMP-dependent transcriptional activation of a number of genes.
C G, Lee, V, da Costa Soares, C, Newberger, K, Manova, E, Lacy, J, Hurwitz   +5 more
openaire   +2 more sources

A helicase links upstream ORFs and RNA structure [PDF]

Current Genetics, 2018
Upstream open reading frames (uORFs) in 5' UTRs of eukaryotic mRNAs are increasingly recognized as important elements that regulate cellular protein synthesis. Since uORFs can start from non-AUG codons, an enormous number of potential uORF initiation sites exists in 5'UTRs.
Eckhard Jankowsky, Ulf-Peter Guenther
openaire   +2 more sources

Helicase: A genetic tool for providing stress tolerance in plants

Plant Stress, 2023
Alteration of stress (abiotic and biotic) constitutes one of the major problems for normal plants health. In the present scenario, new molecular tools are broadly utilized to improve stress tolerance and high-yielding crop plants.
Monalisha Das Mohapatra, Sowmya Poosapati, Ranjan Kumar Sahoo, Durga Madhab Swain   +3 more
doaj   +1 more source

Role reversal of functional identity in host factors: Dissecting features affecting pro-viral versus antiviral functions of cellular DEAD-box helicases in tombusvirus replication.

PLoS Pathogens, 2020
Positive-stranded (+)RNA viruses greatly exploit host cells to support viral replication. However, unlike many other pathogens, (+)RNA viruses code for only a limited number of genes, making them highly dependent on numerous co-opted host factors for ...
Cheng-Yu Wu, Peter D Nagy
doaj   +1 more source

Methotrexate, an anti-inflammatory drug, inhibits Hepatitis E viral replication

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Hepatitis E Virus (HEV) is a positively oriented RNA virus having a 7.2 kb genome. HEV consists of three open reading frames (ORF1-3). Of these, ORF1 codes for the enzymes Methyltransferase (Mtase), Papain-like cysteine protease (PCP), RNA helicase, and ...
Akash Kumar, Preeti Hooda, Anindita Puri, Radhika Khatter, Mohammed S. Al-Dosari, Neha Sinha, Mohammad K. Parvez, Deepak Sehgal   +7 more
doaj   +1 more source

Coordinated function of cellular DEAD-box helicases in suppression of viral RNA recombination and maintenance of viral genome integrity. [PDF]

PLoS Pathogens, 2015
The intricate interactions between viruses and hosts include an evolutionary arms race and adaptation that is facilitated by the ability of RNA viruses to evolve rapidly due to high frequency mutations and genetic RNA recombination.
Chingkai Chuang, K Reddisiva Prasanth, Peter D Nagy   +2 more
doaj   +1 more source

The RNA helicase A in malignant transformation

Oncotarget, 2016
The RNA helicase A (RHA) is involved in several steps of RNA metabolism, such as RNA processing, cellular transit of viral molecules, ribosome assembly, regulation of transcription and translation of specific mRNAs. RHA is a multifunctional protein whose roles depend on the specific interaction with different molecular partners, which have been ...
Fidaleo M., De Paola E., Paronetto M. P.
openaire   +4 more sources

RNA Helicase A Mediates Association of CBP with RNA Polymerase II [PDF]

Cell, 1997
The coactivator CBP has been proposed to stimulate the expression of certain signal-dependent genes via its association with RNA polymerase II complexes. Here we show that complex formation between CBP and RNA polymerase II requires RNA helicase A (RHA), a nuclear DNA/RNA helicase that is related to the Drosophila male dosage compensation factor mle ...
Nakajima, Toshihiro, Uchida, Chiharu, Anderson, Stephen F., Lee, Chee-Gun, Hurwitz, Jerard, Parvin, Jeffrey D., Montminy, Marc   +6 more
openaire   +2 more sources

Structural basis of Zika virus helicase in recognizing its substrates

Protein & Cell, 2016
The recent explosive outbreak of Zika virus (ZIKV) infection has been reported in South and Central America and the Caribbean. Neonatal microcephaly associated with ZIKV infection has already caused a public health emergency of international concern.
Hongliang Tian, Xiaoyun Ji, Xiaoyun Yang, Zhongxin Zhang, Zuokun Lu, Kailin Yang, Cheng Chen, Qi Zhao, Heng Chi, Zhongyu Mu, Wei Xie, Zefang Wang, Huiqiang Lou, Haitao Yang, Zihe Rao   +14 more
doaj   +1 more source