Results 31 to 40 of about 92,282 (271)
DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation. [PDF]
PLoS Pathogens, 2014 RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another DExD/H-box RNA helicase DHX36 is a key molecule for RIG-I signaling by ...
Ji-Seung Yoo +12 more
doaj +1 more source
Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism. [PDF]
PLoS ONE, 2013 RNA helicase A (RHA) promotes multiple steps in HIV-1 production including transcription and translation of viral RNA, annealing of primer tRNA(Lys3) to viral RNA, and elevating the ratio of unspliced to spliced viral RNA.
Li Xing +3 more
doaj +1 more source
mBio, 2023 Coronaviruses (CoVs) encode nonstructural proteins 1–16 (nsps 1–16) which form replicase complexes that mediate viral RNA synthesis. Remdesivir (RDV) is an adenosine nucleoside analog antiviral that inhibits CoV RNA synthesis.
Samantha L. Grimes +12 more
doaj +1 more source
The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription. [PDF]
PLoS ONE, 2016 RNA helicase family members exhibit diverse cellular functions, including in transcription, pre-mRNA processing, RNA decay, ribosome biogenesis, RNA export and translation.
Nian Xiang +10 more
doaj +1 more source
PLoS Pathogens, 2015 RNA helicases and chaperones are the two major classes of RNA remodeling proteins, which function to remodel RNA structures and/or RNA-protein interactions, and are required for all aspects of RNA metabolism.
Hongjie Xia +12 more
doaj +1 more source
Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12
Brazilian Journal of Medical and Biological Research, 2001 DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension
A.A. Camargo +6 more
doaj +1 more source
RNA helicase A interacts with dsDNA and topoisomerase IIalpha [PDF]
Nucleic Acids Research, 2003 RNA helicase A (RHA) is a multifunctional protein involved in various nuclear processes such as transcription and RNA export. It is believed that the interacting factors play important roles in determining the functional specificity of RHA. Here we show that RHA directly interacts with double-stranded (ds) nucleic acids (NAs) and assembles complexes ...
Kai, Zhou +5 more
openaire +2 more sources
Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase
mSphere, 2016 Middle East respiratory syndrome coronavirus (MERS-CoV) helicase is a superfamily 1 helicase containing seven conserved motifs. We have cloned, expressed, and purified a Strep-fused recombinant MERS-CoV nonstructural protein 13 (M-nsp13) helicase ...
Adeyemi O. Adedeji, Hilary Lazarus
doaj +1 more source
Detection of dsRNA-binding domains in RNA helicase A andDrosophilamaleless: implications for monomeric RNA helicases [PDF]
Nucleic Acids Research, 1994 Searches with dsRNA-binding domain profiles detected two copies of the domain in each of RNA helicase A, Drosophila maleless and C. elegans ORF T20G5-11 (of unknown function). RNA helicase A is unusual in being one of the few characterised DEAD/DExH helicases that are active as monomers.
T J, Gibson, J D, Thompson
openaire +2 more sources
Bio-Protocol, 2014 Helicases are a class of enzymes which are motor proteins using energy derived from ATP hydrolysis to move directionally along a nucliec acid phosphodiester backbone (such as DNA, RNA and DNA-RNA hybrids) and separate two annealed nucleic acid strands ...
Xin Wang +3 more
doaj +1 more source