Results 211 to 220 of about 508,217 (335)

Characterization of RNA interference in the cnidarian Nematostella vectensis reveals partial target silencing but lack of small RNA amplification. [PDF]

PLoS Biol
Admoni Y, Lewandowska M, Aharoni R, Shi J, Zhang X, Chen Q, Moran Y.   +6 more
europepmc   +1 more source

Development of a Personalized Visualization and Analysis Tool to Improve Clinical Care in Complex Multisystem Diseases With Application to Scleroderma

Arthritis Care &Research, EarlyView.
Objective In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently, and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of the trajectory of a ...
Ji Soo Kim, John Scott, Lauren Fisher, Lauren N. Smith, Willie Stewart, Adrianne Woods, Rob Smithwright, Diane Koher, Parastoo Aslanbeik, Aalok B. Shah, Brad Tibbils, Samantha I. Pitts, Ayse P. Gurses, Yushi Yang, Ana‐Maria Orbai, Antony Rosen, Laura K. Hummers, Scott L. Zeger, Ami A. Shah   +18 more
wiley   +1 more source

RNA Interference of the Genes Associated with the Invasion of Brain Tumor Cells. [PDF]

Acta Naturae
Dymova MA, Kartina OA, Drokov DV, Kuligina EV, Richter VA.   +4 more
europepmc   +1 more source

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐modifying Antirheumatic Drug

Arthritis Care &Research, Accepted Article.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD) Methods PrismRA incorporated 19 gene expression features and 4 clinical features to assess a patient's likelihood of ...
Fenglong Xie, Timothy Beukelman, Nicholas P McCormick, Jeffrey R Curtis   +3 more
wiley   +1 more source

Figure S5. Degradation of naked and liposome-encapsulated dsRNA in gut contents from Efficiency of RNA interference is improved by knockdown of dsRNA nucleases in tephritid fruit flies

, 2019
Alison Tayler, Daniel Heschuk, David Giesbrecht, Jae Yeon Park, Steve Whyard   +4 more
openalex   +2 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

An RNA interference therapeutic potentially achieves functional cure of chronic hepatitis B virus infection. [PDF]

Nat Commun
Huang ZA, Yang Y, Yang S, Ji GS, Fu R, Tian ZK, Wu YC, Song GS.   +7 more
europepmc   +1 more source

RNA interference-based nanosystems for inflammatory bowel disease therapy

, 2016
Guo J, Jiang XJ, Gui SY
openalex   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Antiviral RNA interference in plants: Increasing complexity and integration with other biological processes. [PDF]

Plant Commun
Li F, Li X, Zhao S, Pan F, Li Z, Hao Y, He J, Wang A, Kormelink R, Zhou X.   +9 more
europepmc   +1 more source