Results 221 to 230 of about 288,613 (251)
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Branched RNA nanostructures for RNA interference
Chemical Communications, 2011Branched RNAs with three- or four-way junctions were designed by assembling single-stranded RNA for RNA interference. Human Dicer transformed branched RNAs into about 20 base pairs of double-stranded RNA, which is a standard siRNA species. Our tetramer design provides a potent silencing effect over a period of 5 days.
Yuko, Nakashima +4 more
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RNA Interference for the Treatment of Cancer
Drug News & Perspectives, 2006RNA interference (RNAi) is the latest new technology in the field of genetic medicine in which specific genes can be turned off, or silenced, so as to affect a therapeutic outcome. It can be highly specific, works in the nanomolar range and is far more effective than the antisense approaches popular 10-15 years ago. Here we review the field and explore
Putral, Lisa N. +2 more
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Antisense-RNA regulation and RNA interference
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002For a long time, RNA has been merely regarded as a molecule that can either function as a messenger (mRNA) or as part of the translational machinery (tRNA, rRNA). Meanwhile, it became clear that RNAs are versatile molecules that do not only play key roles in many important biological processes like splicing, editing, protein export and others, but can ...
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2007
Publisher Summary This chapter discusses the possible roles for RNA interference (RNAi) in the human immunodeficiency virus type 1 (HIV‐1) life cycle and the way in which HIV‐1 might use protein and RNA elements to regulate RNA‐based viral restriction. RNAi can regulate a variety of biological processes.
Le, S, Yeung, ML, Bennasser, Y, Jeang, K
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Publisher Summary This chapter discusses the possible roles for RNA interference (RNAi) in the human immunodeficiency virus type 1 (HIV‐1) life cycle and the way in which HIV‐1 might use protein and RNA elements to regulate RNA‐based viral restriction. RNAi can regulate a variety of biological processes.
Le, S, Yeung, ML, Bennasser, Y, Jeang, K
openaire +4 more sources
Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension
New England Journal of Medicine, 2023Gabriel J Robbie +2 more
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RNA Interference: From Basic Research to Therapeutic Applications
Angewandte Chemie - International Edition, 2009Jens Kurreck
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