Results 31 to 40 of about 2,067,543 (238)
Molecular mechanisms influencing efficiency of RNA interference in insects.
Pest Management Science, 2018 RNA interference (RNAi) is an endogenous, sequence-specific gene-silencing mechanism elicited by small RNA molecules. RNAi is a powerful reverse genetic tool, and is currently being utilized for managing insects and viruses.
Anastasia M W Cooper +4 more
semanticscholar +1 more source
Modeling recursive RNA interference. [PDF]
PLoS Computational Biology, 2008 An important application of the RNA interference (RNAi) pathway is its use as a small RNA-based regulatory system commonly exploited to suppress expression of target genes to test their function in vivo.
Wallace F Marshall
doaj +1 more source
miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities
Cells, 2023 MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological ...
Wilson Huang +3 more
doaj +1 more source
Evidence For Long-Lasting Transgenerational Antiviral Immunity in Insects
Cell Reports, 2020 Summary: Transgenerational immune priming (TGIP) allows memory-like immune responses to be transmitted from parents to offspring in many invertebrates.
Juan A. Mondotte +8 more
doaj
microRNA Therapeutics in Cancer — An Emerging Concept
EBioMedicine, 2016 MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression.
Maitri Y. Shah +4 more
doaj +1 more source
Unzipping and binding of small interfering RNA with single walled Carbon Nanotube: a platform for small interfering RNA delivery [PDF]
J. Chem. Phys. 136, 065106 (2012), 2012 In an effort to design efficient platform for siRNA delivery, we combine all atom classical and quantum simulations to study the binding of small interfering RNA (siRNA) by pristine single wall carbon nanotube (SWCNT). Our results show that siRNA strongly binds to SWCNT surface via unzipping its base-pairs and the propensity of unzipping increases with
arxiv +1 more source
Frontiers in Plant Science, 2017 Plant reoviruses are able to multiply in gramineae plants and delphacid vectors encountering different defense strategies with unique features. This study aims to comparatively assess alterations of small RNA (sRNA) populations in both hosts upon virus ...
Luis A. de Haro +14 more
doaj +1 more source
Slicing and dicing viruses: antiviral RNA interference in mammals
EMBO Journal, 2019 To protect against the harmful consequences of viral infections, organisms are equipped with sophisticated antiviral mechanisms, including cell‐intrinsic means to restrict viral replication and propagation. Plant and invertebrate cells utilise mostly RNA
P. Maillard +3 more
semanticscholar +1 more source
P granules protect RNA interference genes from silencing by piRNAs
bioRxiv, 2019 P granules are perinuclear condensates in C. elegans germ cells proposed to serve as hubs for self/non-self RNA discrimination by Argonautes. We report that a mutant (meg-3 meg-4) that does not assemble P granules in primordial germ cells loses ...
J. P. T. Ouyang +7 more
semanticscholar +1 more source
A Bayesian measurement error model for two-channel cell-based RNAi data with replicates [PDF]
Annals of Applied Statistics 2012, Vol. 6, No. 1, 356-382, 2012 RNA interference (RNAi) is an endogenous cellular process in which small double-stranded RNAs lead to the destruction of mRNAs with complementary nucleoside sequence. With the production of RNAi libraries, large-scale RNAi screening in human cells can be conducted to identify unknown genes involved in a biological pathway.
arxiv +1 more source