Results 31 to 40 of about 508,217 (335)
A genome‐scale screen reveals context‐dependent ovarian cancer sensitivity to miRNA overexpression
Molecular Systems Biology, 2015 Large‐scale molecular annotation of epithelial ovarian cancer (EOC) indicates remarkable heterogeneity in the etiology of that disease. This diversity presents a significant obstacle against intervention target discovery.
Benjamin B Shields +18 more
doaj +1 more source
miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities
Cells, 2023 MicroRNAs (miRNAs) are a type of non-coding RNA whose dysregulation is frequently associated with the onset and progression of human cancers. miR-142, an ultra-conserved miRNA with both active -3p and -5p mature strands and wide-ranging physiological ...
Wilson Huang +3 more
doaj +1 more source
Short-interference RNAs: becoming medicines [PDF]
, 2015 RNA interference is a cellular mechanism by which small molecules of double stranded RNA modulate gene expression acting on the concentration and/or availability of a given messenger RNA.
Jiménez, Ana Isabel +2 more
core +1 more source
microRNA Therapeutics in Cancer — An Emerging Concept
EBioMedicine, 2016 MicroRNAs (miRNAs) are an evolutionarily conserved class of small, regulatory non-coding RNAs that negatively regulate protein coding gene and other non-coding transcripts expression.
Maitri Y. Shah +4 more
doaj +1 more source
Random model for RNA interference yields scale free network
, 2003 We introduce a random bit-string model of post-transcriptional genetic regulation based on sequence matching. The model spontaneously yields a scale free network with power law scaling with $ \gamma=-1$ and also exhibits log-periodic behaviour.
Balcan, Duygu, Erzan, Ayse
core +1 more source
Massive gene amplification on a recently formed Drosophila Y chromosome. [PDF]
, 2019 Widespread loss of genes on the Y is considered a hallmark of sex chromosome differentiation. Here we show that the initial stages of Y evolution are driven by massive amplification of distinct classes of genes. The neo-Y chromosome of Drosophila miranda
Bachtrog, Doris +2 more
core +1 more source
Frontiers in Plant Science, 2017 Plant reoviruses are able to multiply in gramineae plants and delphacid vectors encountering different defense strategies with unique features. This study aims to comparatively assess alterations of small RNA (sRNA) populations in both hosts upon virus ...
Luis A. de Haro +14 more
doaj +1 more source
Microbiome composition modulates the lethal outcome of Drosophila A virus infection
Cellular and Molecular Life SciencesHost-associated microbiomes can strongly influence viral infection outcomes, yet how minor variations in commensal bacterial composition modulate viral pathogenesis remain poorly understood.
Rubén González +6 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
RNA interference targets arbovirus replication in Culicoides cells [PDF]
, 2013 This work was supported by United Kingdom Medical Research Council and Wellcome Trust.Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks, and midges.
Elliott, Richard M. +8 more
core +3 more sources