Results 71 to 80 of about 2,276,335 (391)

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Limited impact of the siRNA pathway on transposable element expression in Aedes aegypti

BMC Biology
Background Transposable elements (TEs) are DNA sequences that can change their position within a genome. In insects, small RNA pathways are central to the transcriptional and post-transcriptional regulation of TE expression.
Alexander Bergman, Anna B. Crist, Hélène Lopez-Maestre, Hervé Blanc, Mauro Castelló-Sanjuán, Lionel Frangeul, Hugo Varet, Josquin Daron, Sarah H. Merkling, Maria-Carla Saleh, Louis Lambrechts   +10 more
doaj   +1 more source

RNA Interference (RNAi) Screening in Drosophila

Genetics, 2018
In the last decade, RNA interference (RNAi), a cellular mechanism that uses RNA-guided degradation of messenger RNA transcripts, has had an important impact on identifying and characterizing gene function. First discovered in Caenorhabditis elegans, RNAi
Florian Heigwer, F. Port, M. Boutros
semanticscholar   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

FABP4 as a key determinant of metastatic potential of ovarian cancer

Nature Communications, 2018
In ovarian cancer, metastatic phenotype may impact surgical outcomes. Here, the authors show miR-409-3p regulates FABP4 which can increase metastatic potential of ovarian cancer, and treatment with DOPC nanoliposomes containing either miR-409--3p mimic ...
Kshipra M. Gharpure, Sunila Pradeep, Marta Sans, Rajesha Rupaimoole, Cristina Ivan, Sherry Y. Wu, Emine Bayraktar, Archana S. Nagaraja, Lingegowda S. Mangala, Xinna Zhang, Monika Haemmerle, Wei Hu, Cristian Rodriguez-Aguayo, Michael McGuire, Celia Sze Ling Mak, Xiuhui Chen, Michelle A. Tran, Alejandro Villar-Prados, Guillermo Armaiz Pena, Ragini Kondetimmanahalli, Ryan Nini, Pranavi Koppula, Prahlad Ram, Jinsong Liu, Gabriel Lopez-Berestein, Keith Baggerly, Livia S. Eberlin, Anil K. Sood   +27 more
doaj   +1 more source

Time-delayed model of RNA interference [PDF]

, 2016
RNA interference (RNAi) is a fundamental cellular process that inhibits gene expression through cleavage and destruction of target mRNA. It is responsible for a number of important intracellular functions, from being the first line of immune defence ...
Agius, Arciero, Bartlett, Bergstrom, Blyuss, Blyuss, Blyuss, Breda, Caplen, Chiu, Dalmay, Elbashir, Elmayan, Escobar, Forrest, G. Neofytou, Giordano, Groenenboom, Groenenboom, Groenenboom, Gu, Hannon, He, Himber, Just, K.B. Blyuss, Ketting, Kuang, Kyrychko, Kyrychko, Kyrychko, Liang, Lipardi, Makeyev, Mandadi, Melnyk, Napoli, Neofytou, Neofytou, Nikolov, Nikolov, Pak, Palauqui, Parmar, Raab, Rahman, Richard, Rodrigo, Ruan, Sharma, Sijen, Smith, Smith, Vaucheret, Y.N. Kyrychko, Zhang   +55 more
core   +2 more sources

RNA Interference as a Prospective Tool for the Control of Human Viral Infections

Frontiers in Microbiology, 2018
RNA interference (RNAi), which is mediated by small interfering RNAs (siRNAs) derived from viral genome or its replicative intermediates, is a natural antiviral defense in plants, fungi, and invertebrates.
Alesia A. Levanova, M. Poranen
semanticscholar   +1 more source

Molecular Mechanisms of RNA Interference [PDF]

Annual Review of Biophysics, 2013
Small RNA molecules regulate eukaryotic gene expression during development and in response to stresses including viral infection. Specialized ribonucleases and RNA-binding proteins govern the production and action of small regulatory RNAs. After initial processing in the nucleus by Drosha, precursor microRNAs (pre-miRNAs) are transported to the ...
Wilson, Ross C, Doudna, Jennifer A
openaire   +5 more sources

Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Rajesha Rupaimoole, Sherry Y. Wu, Sunila Pradeep, Cristina Ivan, Chad V. Pecot, Kshipra M. Gharpure, Archana S. Nagaraja, Guillermo N. Armaiz-Pena, Michael McGuire, Behrouz Zand, Heather J. Dalton, Justyna Filant, Justin Bottsford Miller, Chunhua Lu, Nouara C. Sadaoui, Lingegowda S. Mangala, Morgan Taylor, Twan van den Beucken, Elizabeth Koch, Cristian Rodriguez-Aguayo, Li Huang, Menashe Bar-Eli, Bradly G. Wouters, Milan Radovich, Mircea Ivan, George A. Calin, Wei Zhang, Gabriel Lopez-Berestein, Anil K. Sood   +28 more
doaj   +1 more source

Enhancing Chemotherapy by RNA Interference

BIO Integration, 2020
Small interfering RNA (siRNA) has shown tremendous potential for treating human diseases in the past decades. siRNA can selectively silence a pathological pathway through the targeting and degradation of a specific mRNA, significantly reducing the off ...
Shuwen Cao, Chunhao Lin, Shunung Liang, Chee Hwee Tan, Phei Er Saw, Xiaoding Xu   +5 more
doaj   +1 more source