Results 81 to 90 of about 2,276,335 (391)
Short-interference RNAs: becoming medicines [PDF]
, 2015 RNA interference is a cellular mechanism by which small molecules of double stranded RNA modulate gene expression acting on the concentration and/or availability of a given messenger RNA.
Jiménez, Ana Isabel +2 more
core +1 more source
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Scientific Reports, 2017 Uterine carcinosarcomas (UCSs) are highly aggressive malignancies associated with poor prognoses and limited treatment options. These tumors are hypothesized to develop from the endometrial adenocarcinoma (EAC) through epithelial-mesenchymal transition ...
Jill H. Tseng +8 more
doaj +1 more source
In silico evidence of the relationship between miRNAs and siRNAs
, 2007 Both short interfering RNAs (siRNAs) and microRNAs (miRNAs) mediate the repression of specific sequences of mRNA through the RNA interference pathway.
Casadio, Rita +4 more
core +1 more source
RNA Interference (RNAi) for plants [PDF]
, 2022 As we are facing global population development, strategies are required to improve agricultural production in the battle against hunger and poverty.
Angzzas Sari binti Mohd Kassim, Angzzas Sari binti Mohd Kassim +3 more
core
RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?
Annual Review of Pharmacology and Toxicology, 2016 A resurgence in clinical trials using RNA interference (RNAi) occurred in 2012. Although there were initial difficulties in achieving efficacious results with RNAi without toxic side effects, advances in delivery and improved chemistry made this ...
Maggie L. Bobbin, J. Rossi
semanticscholar +1 more source
RNA interference screening demystified [PDF]
Journal of Clinical Pathology, 2009 Genetic screens, where the effects of modifying gene function on cell behaviour are assessed in a systematic fashion, have for some time provided useful information to those interested in disease pathogenesis and treatment. Genetic screens exploiting the phenomenon of RNA interference (RNAi) are now becoming commonplace.
Christopher J. Lord +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker +14 more
wiley +1 more source
Thrombosis Update, 2021 Objective: Venous thromboembolism (VTE) contributes to morbidity and mortality in women with ovarian cancer. Underlying mechanisms of venous thrombosis in ovarian cancer are not well-understood. The aim of this study was to identify the potential role of
Tomoyuki Sasano +6 more
doaj