Results 81 to 90 of about 300,627 (235)

Assembling biological boolean networks using manually curated databases and prediction algorithms [PDF]

arXiv, 2014
Despite the large quantity of information available, thorough researches in various biological databases are still needed in order to reconstruct and understand the steps that lead to known or new phenomena. By using protein-protein interaction networks and algorithms to extract relevant interconnections among proteins of interest, it is possible to ...
arxiv  

Patent Citation Spectroscopy (PCS): Algorithmic retrieval of landmark patents [PDF]

arXiv, 2017
One essential component in the construction of patent landscapes in biomedical research and development (R&D) is identifying the most seminal patents. Hitherto, the identification of seminal patents required subject matter experts within biomedical areas. In this brief communication, we report an analytical method and tool, Patent Citation Spectroscopy
arxiv  

Impact of the Transboundary Interference Inhibitor on RNAi and the Baculovirus Expression System in Insect Cells

Insects
RNA interference inhibitors were initially discovered in plant viruses, representing a unique mechanism employed by these viruses to counteract host RNA interference.
Hao Zheng, Hengfeng Zhao, Haifan Xiong, Mian Muhammad Awais, Songrong Zeng, Jingchen Sun   +5 more
doaj   +1 more source

Combinatorics Of RNA Structures With Pseudoknots [PDF]

arXiv, 2007
In this paper we derive the generating function of RNA structures with pseudoknots. We enumerate all $k$-noncrossing RNA pseudoknot structures categorized by their maximal sets of mutually intersecting arcs. In addition we enumerate pseudoknot structures over circular RNA. For 3-noncrossing RNA structures and RNA secondary structures we present a novel
arxiv  

Heparin interference with reverse transcriptase polymerase chain reaction of RNA extracted from lungs after ischemia-reperfusion [PDF]

, 2000
Xiaohui Bai, Stefan Fischer, Shaf Keshavjee, Xiaoqing Liu   +3 more
openalex   +1 more source

HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis

Nature Communications
Metabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark of inflammatory bowel diseases.
Agnieszka K. Czopik, Eóin N. McNamee, Victoria Vaughn, Xiangsheng Huang, In Hyuk Bang, Trent Clark, Yanyu Wang, Wei Ruan, Tom Nguyen, Joanne C. Masterson, Eunyoung Tak, Sandra Frank, Colm B. Collins, Howard Li, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Mark E. Gerich, Glenn T. Furuta, Xiaoyi Yuan, Anil K. Sood, Edwin F. de Zoeten, Holger K. Eltzschig   +21 more
doaj   +1 more source

MDM2 inhibitor induces apoptosis in colon cancer cells through activation of the CHOP-DR5 pathway, independent of p53 phenotype

Frontiers in Pharmacology
IntroductionMurine double minute 2 (MDM2), a key negative regulator of p53, forms a feedback loop with p53 to drive tumor progression, including colorectal cancer.
Manman Lu, Manman Lu, Yingli Ren, Sijia Feng, Shenggen Wang, Weiyue Xia, Baoru Gu, Yuhou Shen, Yuhou Shen, Aimin Yue, Aimin Yue, Na Li, Yongxi Zhang, Yongxi Zhang, Jiateng Zhong, Jiateng Zhong, Jiateng Zhong   +16 more
doaj   +1 more source

3D RNA and functional interactions from evolutionary couplings [PDF]

arXiv, 2015
Non-coding RNAs are ubiquitous, but the discovery of new RNA gene sequences far outpaces research on their structure and functional interactions. We mine the evolutionary sequence record to derive precise information about function and structure of RNAs and RNA-protein complexes.
arxiv  

RNA-GPT: Multimodal Generative System for RNA Sequence Understanding [PDF]

arXiv
RNAs are essential molecules that carry genetic information vital for life, with profound implications for drug development and biotechnology. Despite this importance, RNA research is often hindered by the vast literature available on the topic. To streamline this process, we introduce RNA-GPT, a multi-modal RNA chat model designed to simplify RNA ...
arxiv  

Genetic interference in Trypanosoma brucei by heritable and inducible double-stranded RNA [PDF]

, 2000
Huafang Shi, Appolinaire Djikeng, Tomer M. Mark, Elizabeth Wirtz, Christian Tschudi, Elisabetta Ullu   +5 more
openalex   +1 more source