Results 71 to 80 of about 4,574 (248)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Systematic discovery of subcellular RNA patterns in the gut epithelium

Genome Biology
Background Subcellular RNA localization is crucial for the spatio-temporal control of protein synthesis and underlies key processes during development, homeostasis, and disease.
Minkyoung Lee, Ilhan E. Acar, Davide Eletto, Srivathsan Adivarahan, Farah Mhamedi, Kristina Handler, Jihyun Lee, Elena Guido Vinzoni, Gustavo Aguilar, Andreas E. Moor   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Evidence for common machinery utilized by the early and late RNA localization pathways in Xenopus oocytes

, 2005
In Xenopus, an early and a late pathway exist for the selective localization of RNAs to the vegetal cortex during oogenesis. Previous work has suggested that distinct cellular mechanisms mediate localization during these pathways.
Chen, Zhao, Betley, J. Nicholas, Heinrich, Bianca, Deshler, James O., Choo, Soheun   +4 more
core   +1 more source

In-stem molecular beacon targeted to a 5'-region of tRNA inclusive of the D arm that detects mature tRNA with high sensitivity.

PLoS ONE, 2019
Cellular functions are regulated by the up- and down-regulation and localization of RNA molecules. Therefore, many RNA detection methods have been developed to analyze RNA levels and localization.
Yuichi Miyoshi, Takashi Ohtsuki, Hiromu Kashida, Hiroyuki Asanuma, Kazunori Watanabe   +4 more
doaj   +1 more source

Characterization of the nuclear and cytosolic transcriptomes in human brain tissue reveals new insights into the subcellular distribution of RNA transcripts

Scientific Reports, 2021
Transcriptome analysis has mainly relied on analyzing RNA sequencing data from whole cells, overlooking the impact of subcellular RNA localization and its influence on our understanding of gene function, and interpretation of gene expression signatures ...
Ammar Zaghlool, Adnan Niazi, Åsa K. Björklund, Jakub Orzechowski Westholm, Adam Ameur, Lars Feuk   +5 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Analyzing RNA Localization Using the RNA Proximity Labeling Method OINC-seq

Bio-Protocol
Thousands of RNAs are localized to specific subcellular locations, and these localization patterns are often required for optimal cell function.
Megan Pockalny, Hei-Yong Lo, Raeann Goering, J. Taliaferro   +3 more
doaj   +1 more source

Interactome of Two Diverse RNA Granules Links mRNA Localization to Translational Repression in Neurons

Cell Reports, 2013
Transport of RNAs to dendrites occurs in neuronal RNA granules, which allows local synthesis of specific proteins at active synapses on demand, thereby contributing to learning and memory.
Renate Fritzsche, Daniela Karra, Keiryn L. Bennett, Foong yee Ang, Jacki E. Heraud-Farlow, Marco Tolino, Michael Doyle, Karl E. Bauer, Sabine Thomas, Melanie Planyavsky, Eric Arn, Anetta Bakosova, Kerstin Jungwirth, Alexandra Hörmann, Zsofia Palfi, Julia Sandholzer, Martina Schwarz, Paolo Macchi, Jacques Colinge, Giulio Superti-Furga, Michael A. Kiebler   +20 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source