Results 111 to 120 of about 1,130,807 (299)

Causes and Consequences of Flavivirus RNA Methylation [PDF]

Frontiers in Microbiology, 2017
Mosquito-borne flaviviruses are important human pathogens that represent global threats to human health. The genomes of these positive-strand RNA viruses have been shown to be substrates of both viral and cellular methyltransferases. N7-methylation of the 5' cap structure is essential for infection whereas 2'-O-methylation of the penultimate nucleotide
openaire   +3 more sources

The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster. [PDF]

, 2011
Gene expression is highly dynamic and many genes show a wide range in expression over several orders of magnitude. This regulation is often mediated by sequence specific transcription factors.
Bag, I., M. Janaki Ramaiah, Ramaiah, M.J., Bag, Indira, Irene Vetter, Boeke Joern, Kremmer Elisabeth, Vetter, I., Imhof Axel, Bhadra Utpal, Bhadra, U., Kremmer, E., Boeke, J., Kremmer, Elisabeth, Axel Imhof, Manika Pal-Bhadra, Boeke, Joern, Utpal Bhadra, Pal-Bhadra, Manika, Indira Bag, Vetter, Irene, Vetter Irene, M Janaki Ramaiah, Pal-Bhadra Manika, Imhof, Axel, Pal-Bhadra, M., Joern Boeke, Bhadra, Utpal, Ramaiah, M. Janaki, Imhof, A., Bag Indira, Elisabeth Kremmer, Ramaiah M. Janaki   +32 more
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Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

H3 K36 Methylation Helps Determine the Timing of Cdc45 Association with Replication Origins [PDF]

, 2009
BackgroundReplication origins fire at different times during S-phase. Such timing is determined by the chromosomal context, which includes the activity of nearby genes, telomeric position effects and chromatin structure, such as the acetylation state of ...
Mariotti, F.R., Maria Vogelauer, Francesca Romana Mariotti, Devanshi Jain, Pryde, F., Jain, D., Alastair Kerr, Kerr, A., Rebecca Curley, Curley, R., Vogelauer, M., Fiona Pryde   +11 more
core   +2 more sources

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

RNA methylation in neurodevelopment and related diseases

Acta Biochimica et Biophysica Sinica
Biological development and genetic information transfer are governed by genetic, epigenetic, transcriptional, and posttranscriptional mechanisms. RNA methylation, the attachment of methyl (-CH 3) groups to RNA molecules, is a posttranscriptional modification that has gained increasing attention in recent years because of its role in RNA ...
Xia Wenjuan, Liu Yue, Lu Jiafeng, Cheung Hoi-Hung, Meng Qingxia, Huang Boxian   +5 more
openaire   +3 more sources

The highly dynamic heterochromatin protein Swi6 mediates degradation of heterochromatic transcripts [PDF]

, 2014
The aim of my thesis was to investigate the mechanism of heterochromatin repression mediated by heterochromatin protein Swi6 in S. pombe. Research over the years challenged the view of heterochromatin as a static and transcriptionally inert structure ...
Stunnenberg, Rieka
core   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

Analyzing the relationship of RNA and DNA methylation with gene expression

Genome Biology
Background DNA 5-methylcytosine (5mC) and RNA N6-methyladenosine (m6A) methylation are prevalent modifications in eukaryotes, both playing crucial roles in gene regulation. Recent studies have explored their crosstalk and impact on transcription. However,
Shangqian Xie, Darren Hagen, Gabrielle M. Becker, Kimberly M. Davenport, Katie A. Shira, Morgan R. Stegemiller, Jacob W. Thorne, Sarem Khilji, Denise Konetchy, Patricia Villamediana, Brenda M. Murdoch, Stephanie D. McKay   +11 more
doaj   +1 more source

RNA-directed DNA methylation [PDF]

Plant Signaling & Behavior, 2010
Epigenetic RNA based gene silencing mechanisms play a major role in genome stability and control of gene expression. Transcriptional gene silencing via RNA-directed DNA methylation (RdDM) guides the epigenetic regulation of the genome in response to disease states, growth, developmental and stress signals.
openaire   +3 more sources