Results 41 to 50 of about 238,840 (242)

Multiple m6A RNA methylation modulators promote the malignant progression of hepatocellular carcinoma and affect its clinical prognosis

BMC Cancer, 2020
Background Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators (“writer,” “eraser,” and “reader” proteins)
Nanfang Qu, Sanyu Qin, Xuemei Zhang, Xiaotong Bo, Zhengchun Liu, Chao Tan, Guiqiong Wen, Haixing Jiang   +7 more
doaj   +1 more source

The role m6A RNA methylation is CNS development and glioma pathogenesis

Molecular Brain, 2021
Epigenetic abnormalities play a crucial role in many tumors, including glioma. RNA methylation occurs as an epigenetic modification similar to DNA methylation and histone modification.
Ting Pan, Fan Wu, Liwen Li, Shiyan Wu, Fang Zhou, Ping Zhang, Caixing Sun, Liang Xia   +7 more
doaj   +1 more source

m6A RNA Methylation Regulators Contribute to Malignant Progression and Have Clinical Prognostic Impact in Gastric Cancer

Frontiers in Oncology, 2019
N6-methyladenosine (m6A) is the most common form of mRNA modification, and is dynamically regulated by the m6A RNA methylation regulators. However, little is known about m6A in gastric cancer. The aim of this work is to investigate the effects of m6A RNA
Yunshu Su, Jinqi Huang, Jichang Hu
doaj   +1 more source

m6A RNA Methylation Regulators Impact Prognosis and Tumor Microenvironment in Renal Papillary Cell Carcinoma

Frontiers in Oncology, 2021
Accumulating evidence has proven that N6-methyladenosine (m6A) RNA methylation plays an essential role in tumorigenesis. However, the significance of m6A RNA methylation modulators in the malignant progression of papillary renal cell carcinoma (PRCC) and
Lianze Chen, Lianze Chen, Baohui Hu, Baohui Hu, Xinyue Song, Xinyue Song, Lin Wang, Lin Wang, Mingyi Ju, Mingyi Ju, Zinan Li, Zinan Li, Chenyi Zhou, Chenyi Zhou, Ming Zhang, Ming Zhang, Qian Wei, Qian Wei, Qiutong Guan, Qiutong Guan, Longyang Jiang, Longyang Jiang, Ting Chen, Ting Chen, Minjie Wei, Minjie Wei, Minjie Wei, Lin Zhao, Lin Zhao   +28 more
doaj   +1 more source

m6A RNA Methylation in Cardiovascular Diseases [PDF]

Molecular Therapy, 2020
Cardiovascular diseases (CVDs) remain the leading cause of death and disability worldwide, despite marked improvements in prevention, diagnosis, and early intervention. There is an urgent need to discover more effective therapeutic strategies, which would be facilitated by a more in-depth understanding of CVDs and their underlying molecular mechanisms.
Siyi, Wu, Shuchen, Zhang, Xiaoguang, Wu, Xiang, Zhou   +3 more
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The de novo cytosine methyltransferase DRM2 requires intact UBA domains and a catalytically mutated paralog DRM3 during RNA-directed DNA methylation in Arabidopsis thaliana. [PDF]

PLoS Genetics, 2010
Eukaryotic DNA cytosine methylation can be used to transcriptionally silence repetitive sequences, including transposons and retroviruses. This silencing is stable between cell generations as cytosine methylation is maintained epigenetically through DNA ...
Ian R Henderson, Angelique Deleris, William Wong, Xuehua Zhong, Hang Gyeong Chin, Gregory A Horwitz, Krystyna A Kelly, Sriharsa Pradhan, Steven E Jacobsen   +8 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Clinical significance of RNA methylation in hepatocellular carcinoma

Cell Communication and Signaling
Hepatocellular carcinoma (HCC) is a primary liver malignancy with high mortality rates and poor prognosis. Recent advances in high-throughput sequencing and bioinformatic technologies have greatly enhanced the understanding of the genetic and epigenetic ...
Qiongling Bao, Yifan Zeng, Qizhuo Lou, Xuewen Feng, Shuwen Jiang, Juan Lu, Bing Ruan   +6 more
doaj   +1 more source